Interleukin-1β, tumor necrosis factor-α, and nitrite levels in febrile seizures
Interleukin-1β, tumor necrosis factor-α, and nitrite levels in febrile seizures
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DOI：
10.1177/08830738020170101501
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发表时间：
2002-10-01
影响因子：
1.9
通讯作者：
Yegin, O
中科院分区：
文献类型：
--
作者：
Haspolat, S;Mihçi, E;Yegin, O
已知促炎细胞因子（如白细胞介素-1 β、肿瘤坏死因子-α）和一氧化氮对兴奋或炎症期间释放的神经元和神经毒性神经递质具有直接和间接的调节作用。我们检测了热性惊厥患儿外周血和脑脊液中的白细胞介素-1 β、肿瘤坏死因子-α和亚硝酸盐水平，并将我们的结果与无惊厥的发热性疾病患儿的结果进行了比较。本文对29例热性惊厥患儿和15例对照组进行了研究。脑脊液中白细胞介素1 β和亚硝酸盐的平均浓度显著升高（P
Proinflammatory cytokines (such as interleukin-1beta, tumor necrosis factor-alpha) and nitric oxide are known to have both direct and indirect modulating effects on neurons and neurotoxic neurotransmitters released during excitation or inflammation. We measured interleukin-1beta, tumor necrosis factor-alpha, and nitrite levels in the peripheral blood and cerebrospinal fluid of children with febrile seizures and compared our results with those of children with febrile illnesses without seizures. Twenty-nine children with febrile seizure and 15 controls were studied. The mean concentrations of interleukin-1beta and nitrite were significantly increased in the cerebrospinal fluid (P