One-pot synthesis of 1H-isochromenes and 1,2-dihydroisoquinolines by a sequential isocyanide-based multicomponent/Wittig reaction
One-pot synthesis of 1H-isochromenes and 1,2-dihydroisoquinolines by a sequential isocyanide-based multicomponent/Wittig reaction
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通过顺序异氰化物多组分/维蒂希反应一锅法合成 1H-异色烯和 1,2-二氢异喹啉
DOI：
10.1039/c5ob02405f
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发表时间：
2016
影响因子：
3.2
通讯作者：
Ding Ming-Wu
中科院分区：
文献类型：
--
作者：
Wang Long;Guan Zhi-Rong;Ding Ming-Wu
采用I-MCR/Wittig程序一锅法合成了1H-异色烯和1，2-二氢异喹啉。鏻盐5、酸、胺（或不含）和异氰化物的反应通过连续的Passerini或Ugi缩合和在K2 CO 3存在下的分子内Wittig反应以良好的产率得到1H-异色烯7或1，2-二氢异喹啉9。
A one-pot synthesis of 1H-isochromenes and 1,2-dihydroisoquinolines by a I-MCR/Wittig sequence was developed. The reaction of phosphonium salt 5, an acid, an amine (or without), and an isocyanide gave the 1H-isochromenes 7 or 1,2-dihydroisoquinolines 9 in good yields by a sequential Passerini or Ugi condensation and an intramolecular Wittig reaction in the presence of K2CO3.