Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors
Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors
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DOI：
10.1016/s0896-6273(00)80898-3
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发表时间：
2000-02-01
期刊：
影响因子：
16.2
通讯作者：
Anderson, DJ
中科院分区：
文献类型：
--
作者：
Zhou, Q;Wang, SL;Anderson, DJ
碱性螺旋-环-螺旋（bHLH）转录因子已被确定为神经元及其前体细胞，但没有神经胶质细胞。我们已经确定了两个bHLH因子，寡核苷酸1和寡核苷酸2，这是专门表达的神经上皮细胞少突胶质细胞前体出现的区域，以及在前体本身。脊髓中Oligo 2的表达先于血小板衍生生长因子受体α（PDGFR α）的表达，PDGFR α是已知最早的少突胶质细胞前体标志物，早于几天。Oligo 2在体内的异位表达导致Sox 10的异位表达，Sox 10是在少突胶质细胞和其他神经胶质前体中表达的HMG盒转录因子。这些数据确定寡聚基因作为最早已知的少突胶质细胞谱系决定的标志物，并表明它们在这一过程中发挥因果作用。
Basic helix-loop-helix (bHLH) transcription factors have been identified for neurons and their precursors but not for glial cells. We have identified two bHLH factors, Oligo1 and Oligo2, that are specifically expressed in zones of neuroepithelium from which oligodendrocyte precursors emerge, as well as in the precursors themselves. Expression of Oligo2 in the spinal cord precedes that of platelet-derived growth factor receptor alpha (PDGFR alpha), the earliest known marker of oligodendrocyte precursors, by several days. Ectopic expression of Oligo2 in vivo causes ectopic expression of Sox10, an HMG-box transcription factor expressed in oligodendrocyte and other glial precursors. These data identify Oligo genes as the earliest known markers of oligodendrocyte lineage determination and suggest they play a causal role in this process.