Age gene expression and coexpression progressive signatures in peripheral blood leukocytes
Age gene expression and coexpression progressive signatures in peripheral blood leukocytes
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DOI：
10.1016/j.exger.2015.09.003
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发表时间：
2015-12-01
影响因子：
3.9
通讯作者：
Otaegui, David
中科院分区：
文献类型：
--
作者：
Irizar, Haritz;Goni, Joaquin;Otaegui, David
众所周知，细胞衰老和组织衰老都是动态的过程，开始于生命的早期，并在个体的整个生命中不断进步。在这项工作中，为了在转录水平上识别与年龄相关的渐进性变化的特征，我们对一组年龄从14岁到93岁的健康个体的外周血白细胞进行了全基因组基因表达分析。一组基因表达逐渐变化(或随年龄增加或减少)的基因已经被识别出来，并在共表达网络中联系起来。对这个网络进行了模块化分析，并对每个模块进行了生物学术语和途径浓缩分析。综上所述，本工作的结果揭示了转录成分的存在，该成分显示了外周血白细胞中与年龄相关的渐进性表达变化，突显了这一过程的动态性质，以及用包括中年人在内的纵向研究来补充年轻与老年研究的必要性。从转录的角度来看，免疫衰老似乎发生在相对较早的年龄，至少从20多岁末/30岁初开始，49-56岁的年龄范围似乎是关键的。总体而言，根据我们的结果，随着年龄的增长，表现出渐进性表达变化的基因参与了致病/细胞过程，这些过程通常与人类的衰老有关：癌症、免疫过程和细胞生长与维持。(C)2015 Elsevier Inc.保留所有权利。
Both cellular senescence and organismic aging are known to be dynamic processes that start early in life and progress constantly during the whole life of the individual. In this work, with the objective of identifying signatures of age-related progressive change at the transcriptomic level, we have performed a whole-genome gene expression analysis of peripheral blood leukocytes in a group of healthy individuals with ages ranging from 14 to 93 years. A set of genes with progressively changing gene expression (either increase or decrease with age) has been identified and contextualized in a coexpression network. A modularity analysis has been performed on this network and biological-term and pathway enrichment analyses have been used for biological interpretation of each module.In summary, the results of the present work reveal the existence of a transcriptomic component that shows progressive expression changes associated to age in peripheral blood leukocytes, highlighting both the dynamic nature of the process and the need to complement young vs. elder studies with longitudinal studies that include middle aged individuals. From the transcriptional point of view, immunosenescence seems to be occurring from a relatively early age, at least from the late 20s/early 30s, and the 49-56 year old age-range appears to be critical. In general, the genes that, according to our results, show progressive expression changes with aging are involved in pathogenic/cellular processes that have classically been linked to aging in humans: cancer, immune processes and cellular growth vs. maintenance. (C) 2015 Elsevier Inc. All rights reserved.