Monoclonal antibodies that recognize a specific surface antigen of Treponema denticola
Monoclonal antibodies that recognize a specific surface antigen of Treponema denticola
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识别齿垢密螺旋体特定表面抗原的单克隆抗体
DOI：
10.1128/iai.56.1.60-63.1988
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发表时间：
1988
影响因子：
3.1
通讯作者：
S. W. Bockowski
中科院分区：
文献类型：
--
作者：
L. Simonson;R. Rouse;S. W. Bockowski
螺旋体是人类牙周炎的潜在病原体。本研究开发了一种口腔螺旋体齿垢密螺旋体血清群特异性鼠单克隆抗体（MAbs），并对其进行了表征。由克隆IAA11分泌的抗体被认为是最有用的，因为它们能够检测15个T中的8个。齿垢菌株。该MAb由免疫球蛋白G3重链和κ轻链组成。发现MAb IAA11与位于细胞壁外鞘上的表位靶标反应。该单克隆抗体对T.人类牙周炎中的齿垢菌群。
Spirochetes have been implicated as potential etiologic agents of periodontitis in humans. Murine monoclonal antibodies (MAbs) specific for a serogroup of Treponema denticola, an oral spirochete, were developed and characterized in this study. Antibodies secreted by clone IAA11 were judged to be the most useful, since they were able to detect 8 of 15 T. denticola strains. This MAb consisted of an immunoglobulin G3 heavy chain and a kappa light chain. MAb IAA11 was found to react with an epitope target located on the outer sheath of the cell wall. This MAb should be of diagnostic and scientific value in the study of T. denticola populations in human periodontitis.