The Amt/Mep/Rh family of ammonium transport proteins (Review)
The Amt/Mep/Rh family of ammonium transport proteins (Review)
复制标题
铵转运蛋白 Amt/Mep/Rh 家族（综述）
作者：
S. Andrade;O. Einsle
整合膜蛋白的NH 4/Mep/Rh家族包括细菌、古细菌和真核生物的铵转运蛋白，以及在动物中发现的恒河猴蛋白。它们在生物合成目的的还原氮的摄取、能量代谢或肾排泄中发挥核心作用。最近的结构信息对两个原核生物的蛋白质有显着的贡献，我们对这一类的理解，但有关运输机制和性质的运输基板，NH3或，仍有待回答的基本问题。在这里，我们回顾的功能和结构的研究，并讨论了生物能量的问题所提出的各种机制的建议，在文献中。
The Amt/Mep/Rh family of integral membrane proteins comprises ammonium transporters of bacteria, archaea and eukarya, as well as the Rhesus proteins found in animals. They play a central role in the uptake of reduced nitrogen for biosynthetic purposes, in energy metabolism, or in renal excretion. Recent structural information on two prokaryotic Amt proteins has significantly contributed to our understanding of this class, but basic questions concerning the transport mechanism and the nature of the transported substrate, NH3 or , remain to be answered. Here we review functional and structural studies on Amt proteins and discuss the bioenergetic issues raised by the various mechanistic proposals present in the literature.
DOI：
10.1073/pnas.95.23.13965
发表时间：
1998-11-10
影响因子：
11.1
作者：
Hsieh, MH;Lam, HM;Coruzzi, G
通讯作者：
Coruzzi, G