Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - The role of Hsp90
Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - The role of Hsp90
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DOI：
10.1016/j.ydbio.2018.02.014
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发表时间：
2018-04-15
影响因子：
2.7
通讯作者：
Raz, Erez
中科院分区：
文献类型：
--
作者：
Pfeiffer, Jana;Tarbashevich, Katsiaryna;Raz, Erez
斑马鱼原始生殖细胞（PGCs）构成了一个有用的体内模型，以研究细胞迁移和阐明在这一过程中的特定蛋白质的作用。在这里，我们报告的热休克蛋白Hsp90aa1.2，蛋白质的RNA水平升高的PGCs在其迁移过程中的作用。降低Hsp90aa1.2活性会减缓细胞周期的进程，并导致迁移细胞中MTOC数量控制的缺陷。这些缺陷导致较慢的迁移速率，并损害PGCs到达其目标，性腺发育的区域。我们的研究结果强调了在单细胞迁移过程中确保细胞周期快速进展的重要性，并强调了热休克蛋白在这一过程中的作用。
Zebrafish primordial germ cells (PGCs) constitute a useful in vivo model to study cell migration and to elucidate the role of specific proteins in this process. Here we report on the role of the heat shock protein Hsp90aa1.2, a protein whose RNA level is elevated in the PGCs during their migration. Reducing Hsp90aa1.2 activity slows down the progression through the cell cycle and leads to defects in the control over the MTOC number in the migrating cells. These defects result in a slower migration rate and compromise the arrival of PGCs at their target, the region where the gonad develops. Our results emphasize the importance of ensuring rapid progression through the cell cycle during single-cell migration and highlight the role of heat shock proteins in the process.