Myelin glycoprotein P0 is expressed at early stages of chicken and rat embryogenesis.
Myelin glycoprotein P0 is expressed at early stages of chicken and rat embryogenesis.
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髓磷脂糖蛋白 P0 在鸡和大鼠胚胎发生的早期阶段表达。
DOI：
10.1002/jnr.490400213
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Brackenbury,R
中科院分区：
文献类型：
--
作者：
Zhang,SM;Marsh,R;Ratner,N;Brackenbury,R
Although previous studies suggest that Po is expressed only in myelinating Schwann cells, monoclonal antibody 1E8 reacts with Po, yet also stains early Schwann cell precursors and non-myelinating Schwann cells (Bhattacharyya et al.: Neuron 7: 831-844, 1991). We therefore characterized the 1E8 epitope and analyzed Po mRNA expression during development. Immunoblot analyses of Po fusion proteins and of deglycosylated Po indicated that the 1E8 epitope is polypeptide. Northern blot and polymerase chain reaction (PCR) analyses revealed that Po is encoded by a single mRNA that is expressed in chicken embryos as early as E4 and in rat embryos as early as E14. These data indicate that the antigen recognized by 1E8 in early chicken embryos is Po and that, during development of both chickens and rats, Po mRNA is expressed long before myelination. 0 1995 Wiley-Liss, Inc.
