Asthma is associated with weight gain in females but not males, independent of physical activity
Asthma is associated with weight gain in females but not males, independent of physical activity
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DOI：
10.1164/ajrccm.164.11.2004235
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发表时间：
2001-12-01
影响因子：
24.7
通讯作者：
Williams, D
中科院分区：
文献类型：
--
作者：
Beckett, WS;Jacobs, DR;Williams, D
我们对4,547名18 - 30岁的非洲裔美国人和白色男性和女性进行了长达10年的前瞻性随访，以检验哮喘诊断是否与体重增加和体力活动有关。基线哮喘在非洲裔美国男性中最常见。哮喘发作在女性中更常见。在调整其他因素后，哮喘发作与最高和最低基线以及体重指数（BMI）变化相关，呈J形曲线。当按性别分层时，这种关联仅见于女性。受试者平均减少体力活动，体重随时间增加，但基线时体力活动的哮喘患病率或体力活动变化的哮喘发病率无显著差异。女性吸烟与哮喘发病率显著相关，但非吸烟者基线血清可替宁水平（反映环境烟草烟雾[ETS]暴露）与哮喘无显著相关。我们的结论是，体重指数的增加易使年轻女性患上新的哮喘，但体力活动的减少不能解释体重增加与哮喘的关系。
We tested whether asthma diagnosis is associated with weight gain and physical activity in 4,547 18 to 30-yr-old African American and white men and women, followed prospectively for up to 10 yr. Baseline asthma was most frequent in African American men. Incident asthma was more frequent in women. Incident asthma was associated with highest and lowest baseline and change in body mass index (BMI), in a J-shaped curve, after adjustment for other factors. When stratified by sex, this association was seen only in females. Subjects on average decreased physical activity and gained weight over time, but there was no significant difference in asthma prevalence by physical activity at baseline or asthma incidence by change in physical activity. Cigarette smoking in females was significantly associated with asthma incidence, but serum cotinine level at baseline among nonsmokers (reflecting environmental tobacco smoke [ETS] exposure) was not significantly associated with asthma. We conclude that gain in BMI predisposes to new asthma diagnosis In female young adults, but decreased physical activity does not explain the association of weight gain with asthma.