EXPRESSION OF THE GROWTH-ASSOCIATED PROTEIN GAP-43 IN ADULT-RAT RETINAL GANGLION-CELLS FOLLOWING AXON INJURY
EXPRESSION OF THE GROWTH-ASSOCIATED PROTEIN GAP-43 IN ADULT-RAT RETINAL GANGLION-CELLS FOLLOWING AXON INJURY
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DOI：
10.1016/0896-6273(91)90066-9
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发表时间：
1991-04-01
期刊：
影响因子：
16.2
通讯作者：
WILLARD, MB
中科院分区：
文献类型：
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作者：
DOSTER, SK;LOZANO, AM;WILLARD, MB
我们研究了生长相关蛋白GAP-43在成年大鼠视网膜神经节细胞（CNS神经元，通常不会再生损伤的轴突）轴突损伤后的表达。 GAP-43的生物合成标记和视网膜的差距-43免疫反应性在轴突切断后增加，但仅当损伤在眼睛的3 mm内时。 这些结果表明以下结论：首先，轴突损伤足以改变CNS神经元中GAP-43的表达，即使在没有再生的情况下。 其次，调节GAP-43表达的机制对损伤后保留的不间断轴突的长度敏感。 最后，有利于增加GAP-43的条件与有利于受损CNS轴突再生长到外周神经移植物中的条件相似，表明GAP-43诱导伴随着受损CNS神经元再生潜力的增加。
We have studied the expression of the growth-associated protein GAP-43 after injury to the axons of adult rat retinal ganglion cells (CNS neurons that do not normally regenerate injured axons). Both the biosynthetic labeling of GAP-43 and the GAP-43 immunoreactivity of the retina increased after axotomy, but only when the injury was within 3 mm of the eye. These results suggest the following conclusions: First, axon injury is sufficient to alter GAP-43 expression in CNS neurons, even in the absence of regeneration. Second, mechanisms that regulate GAP-43 expression are sensitive to the length of uninterrupted axon remaining after injury. Finally, the conditions that favor increased GAP-43 are similar to those that favor regrowth of injured CNS axons into grafts of peripheral nerve, suggesting that GAP-43 induction is accompanied by an increased potential of injured CNS neurons to regenerate.