PROTEIN-STRUCTURE ALIGNMENT
PROTEIN-STRUCTURE ALIGNMENT
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DOI：
10.1016/0022-2836(89)90084-3
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发表时间：
1989-07-05
影响因子：
5.6
通讯作者：
ORENGO, CA
中科院分区：
文献类型：
--
作者：
TAYLOR, WR;ORENGO, CA
提出了一种基于距离图分析的蛋白质结构比较方法。它对序列中的插入和缺失相对不敏感，并且容忍比较的两个分子之间的等同亚结构的置换。当呈现两个结构的坐标集时，该方法将基于结构标准自动产生它们的序列的比对。该方法采用了蛋白质序列比较中广泛应用的动态规划优化技术，将蛋白质结构和序列比较技术有机地结合起来。典型的结构比较的问题进行了检查和新方法的结果相比，使用传统的方法获得的公布的结果。在大多数实例中，新方法产生的结果与文献中报道的结果相当，在某些情况下上级文献中报道的结果。
A new method of comparing protein structures is described, based on distance plot analysis. It is relatively insensitive to insertions and deletions in sequence and is tolerant of the displacement of equivalent substructures between the two molecules bing compared. When presented with the co-ordinate sets of two structures, the method will produce automatically an alignment of their sequences based on structural criteria. The method uses the dynamic programming optimization technique, which is widely used in the comparison of protein sequences and thus unifies the techniques of protein structure and sequence comparison. Typical structure comparison problems were examined and the results of the new method compared to the published results obtained using conventional methods. In most examples, the new method produced a result that was equivalent, and in some cases superior, to those reported in the literature.