Telomeres are shorter and associated with number of suicide attempts in affective disorders
Telomeres are shorter and associated with number of suicide attempts in affective disorders
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DOI：
10.1016/j.jad.2021.08.135
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发表时间：
2021-09-16
影响因子：
6.6
通讯作者：
Aas, Monica
中科院分区：
文献类型：
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作者：
Birkenaes, Viktoria;Elvsashagen, Torbjorn;Aas, Monica
背景：较短的端粒长度是加速衰老的假定生物标志物，并与情感障碍和死亡率相关。与端粒缩短相关的心理因素和行为尚待澄清。在这里，我们调查了情感性精神障碍患者的自杀企图史和端粒长度之间的关系。通过实时定量聚合酶链反应（qPCR）测定了情感障碍患者（n = 248）的白细胞端粒长度，包括双相情感障碍I型（n = 159）、II型（n = 67）、重度抑郁症（n = 22）、健康对照组（n = 401）。诊断、病程和发病年龄采用DSM-IV结构性临床访谈（SCID-I）进行评估。终生自杀企图的数量基于自我报告。结果：与健康对照组相比，情感性精神障碍患者的端粒长度减少（d = 0.18，F = 5.26，p = 0.02）。在患者中，自杀企图次数越多，端粒长度越短（β = 0.24，t = 3.83，CI = 0.44至0.14，p < 0.001），在控制疾病持续时间和发病年龄时也是如此（β = 0.23，CI = 0.42至0.12，p = 0.001）。多次自杀企图与端粒长度减少相媲美，8年的寿命，调整人口和临床characteristics.Conclusions：虽然纵向数据需要澄清的时间过程中，以前的自杀企图和相关的困扰可能会加速端粒缩短和衰老的情感障碍患者。
Background: Shorter telomere length is a putative biomarker of accelerated aging and has been associated with affective disorders and mortality. Psychological factors and behaviors associated with telomere shortening are yet to be clarified. Here, we investigate the association between history of suicide attempts and telomere length in patients with affective disorders.Methods: Leucocyte telomere length was determined by quantitative real-time Polymerase Chain Reaction (qPCR) in patients with affective disorders (n = 248) including bipolar disorders type I (n = 159), type II (n = 67), major depressive disorder (n = 22), and healthy controls (n = 401). Diagnosis, duration of illness, and age at onset were assessed using the Structural Clinical Interview for DSM-IV (SCID-I). Number of lifetime suicide attempts were based on self-reports. Effect size was calculated using Cohen's d.Results: Telomere length was reduced in patients with affective disorders relative to healthy controls (d = 0.18, F = 5.26, p = 0.02). Among patients, a higher number of suicide attempts was associated with shorter telomere length (beta = 0.24, t = 3.83, CI = 0.44 to 0.14, p < 0.001), also when controlling for duration of illness and age at onset (beta =.23, CI =.42 to.12, p = 0.001). Multiple suicide attempts were associated with telomere length reduction comparable to eight years lifespan, adjusted for demographic and clinical characteristics.Conclusions: While longitudinal data are needed to clarify the temporal course, previous suicide attempts and related distress may accelerate telomere shortening and aging in patients with affective disorders.