Evaluation of glutathione-binding protein A of Haemophilus parasuis as a vaccine candidate in a mouse model.
Evaluation of glutathione-binding protein A of Haemophilus parasuis as a vaccine candidate in a mouse model.
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副猪嗜血杆菌谷胱甘肽结合蛋白 A 作为候选疫苗在小鼠模型中的评价
DOI：
10.1292/jvms.16-0327
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发表时间：
2017-01-24
期刊：
影响因子：
--
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Zhang Y;Li G;Xie F;Liu S;Wang C
副猪嗜血杆菌的强毒株是格拉瑟氏病的病原体，可引起全身感染并导致多发性浆膜炎、脑膜炎和关节炎。新型有效疫苗的开发将有利于预防副猪嗜血菌感染。在此，我们报告了一种新型免疫原性蛋白，即谷胱甘肽结合蛋白 A (GbpA)，它可以引发显着的体液抗体反应，并针对致命剂量的高毒力副猪嗜血菌菌株的攻击提供显着的保护作用。免疫小鼠体内的副猪嗜血菌菌株可以被完全消除。结果表明，GbpA 有潜力用作新型副猪嗜血菌疫苗的有效成分。
The virulent strains of Haemophilus parasuis are the causative agents of Glässer’s disease, which can cause systemic infection and result in polyserositis, meningitis and arthritis. The development of novel, effective vaccines would be beneficial to preventing H. parasuis infections. Here, we report a novel immunogenic protein, glutathione-binding protein A (GbpA), which can elicit a significant humoral antibody response and confer significant protection against challenge with a lethal dose of a highly virulent H. parasuis strain. The H. parasuis strain can be fully eliminated in the immunized mice. The results indicate that GbpA has the potential to be used as an effective component of a new vaccine against H. parasuis.