Circulating long-chain acylcarnitine concentrations are not affected by exercise training in pregnant women with obesity.
Circulating long-chain acylcarnitine concentrations are not affected by exercise training in pregnant women with obesity.
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肥胖孕妇的循环长链酰基肉碱浓度不受运动训练的影响。
DOI：
10.1152/japplphysiol.00712.2021
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Børsheim,Elisabet
中科院分区：
文献类型：
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作者：
Allman,BrittanyR;Spray,BeverlyJ;Lan,RennyS;Andres,Aline;Børsheim,Elisabet
本研究的目的是确定长期久坐的肥胖妇女在怀孕期间运动对长链酰基肉毒碱（LC-AC）浓度纵向变化的影响。我们假设，与非运动对照组相比，运动训练将显著降低整个妊娠期循环LC-AC。将被认为健康的肥胖孕妇[n= 80，平均值± SD;体重指数（BMI）：36.9 ± 5.7 kg/m2]随机分为运动组（n= 40，有氧/阻力3次/周，妊娠第13周至出生）或非运动对照组（n= 40）。在孕12.2 ± 0.5和36.0 ± 0.4周进行次极量运动试验，并使用间接热量测定法测量相对静息能量消耗（REE）以及静息呼吸交换率（RER）。采集空腹血样并分析LC-AC浓度。产前运动训练可改善健康状况;然而，运动训练并不影响循环LC-AC。当组被折叠时，LC-AC在妊娠期间降低（组合组，P< 0.001），而REE（kcal/kg/d，P= 0.008）增加。然而，平均REE相对于无脂肪质量（FFM）（千卡/千克FFM/天）和RER没有变化。在整个妊娠期间，RER的变化与所有LC-AC（C18：2除外）之间呈负相关（C14：r=-0.26，P = 0.04; C16：r=-0.27，P = 0.03; C18：1：r=-0.28，P = 0.02）。总之，与对照组相比，肥胖妇女怀孕期间的中等强度运动干预并没有改变LC-AC浓度，表明运动干预既没有改善也没有恶化长链脂肪酸可用性和氧化之间的平衡。在整个妊娠期间，对母体和后代的基质供应和需求的正常变化没有负面影响。研究结果为怀孕期间运动的代谢安全性提供了支持。
The purpose of this study was to determine the effect of exercise during pregnancy in sedentary women with obesity on longitudinal changes in long-chain acylcarnitine (LC-AC) concentrations. We hypothesized that exercise training would significantly decrease circulating LC-ACs throughout gestation compared with a nonexercise control group. Pregnant women with obesity considered otherwise healthy [n= 80, means ± SD; body mass index (BMI): 36.9 ± 5.7 kg/m2] were randomized into an exercise (n= 40, aerobic/resistance 3 times/wk, ∼13th gestation week until birth) or a nonexercise control (n= 40) group. At gestation week 12.2 ± 0.5 and 36.0 ± 0.4, a submaximal exercise test was conducted, and indirect calorimetry was used to measure relative resting energy expenditure (REE), as well as respiratory exchange ratio (RER) at rest. Fasting blood samples were collected and analyzed for LC-AC concentrations. Fitness improved with prenatal exercise training; however, exercise training did not affect circulating LC-AC. When groups were collapsed, LC-ACs decreased during gestation (combined groups,P< 0.001), whereas REE (kcal/kg/day,P= 0.008) increased. However, average REE relative to fat-free mass (FFM) (kcal/kg FFM/day) and RER did not change. There was an inverse relationship between the change in RER and all LC-ACs (except C18:2) throughout gestation (C14:r= −0.26,P= 0.04; C16:r= −0.27,P= 0.03; C18:1:r= −0.28,P= 0.02). In summary, a moderate-intensity exercise intervention during pregnancy in women with obesity did not alter LC-ACs concentrations versus control, indicating that the balance between long-chain fatty acid availability and oxidation neither improved nor worsened with an exercise intervention.NEW & NOTEWORTHYThis research showed that a moderate-intensity prenatal exercise program, consisting of aerobic and resistance training, did not negatively impact normal alterations in substrate supply and demand for the mother and the offspring throughout gestation. Findings provide support for metabolic safety of exercise during pregnancy.