ACOUSTIC CHARACTERIZATION OF TISSUE-MIMICKING MATERIALS FOR ULTRASOUND PERFUSION IMAGING RESEARCH
ACOUSTIC CHARACTERIZATION OF TISSUE-MIMICKING MATERIALS FOR ULTRASOUND PERFUSION IMAGING RESEARCH
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DOI：
10.1016/j.ultrasmedbio.2021.09.004
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发表时间：
2022-01-01
影响因子：
2.9
通讯作者：
Mischi, Massimo
中科院分区：
文献类型：
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作者：
Chen, Peiran;Pollet, Andreas M. A. O.;Mischi, Massimo
具有良好声学特性的材料对于具有设计的（微）脉管系统网络的仿组织体模的开发具有极大的兴趣。这些代表了用于受控体外实验以验证灌注成像方法（例如多普勒和对比增强超声（CEUS）成像）的有用手段。在这项工作中，声学性能的七个组织模仿体模材料在不同浓度的化合物和五个幻影情况下的材料的特点和比较在室温下。本研究的目的是确定最适合超声灌注成像实验的体模和外壳材料。测量结果显示，对于不同的体模材料，声速范围从1057 m/s到1616 m/s不等，声阻抗范围从1.09 x 10（6）kg/m（2）s到1.71 x 10（6）kg/m（2）s不等，衰减系数范围从0.1 dB/cm到22.18 dB/cm不等，频率范围从1 MHz到6 MHz不等。对于大多数体模材料，非线性参数B/A在6.1到12.3之间变化。本文还报道了壳体材料的声速、声阻抗和衰减系数。根据实验结果，聚丙烯酰胺（PAA）和聚甲基戊烯（TPX）分别是最佳的模体材料和外壳材料。为了证明最佳材料的性能，我们对可灌注体模进行了功率多普勒超声成像，并对该体模和灌注系统进行了CEUS成像。所获得的结果可以帮助研究人员选择最合适的材料进行超声成像的体外研究。(C)2021年，任作者。爱思唯尔公司出版代表世界超声波医学与生物学联合会。
Materials with well-characterized acoustic properties are of great interest for the development of tissue-mimicking phantoms with designed (micro)vasculature networks. These represent a useful means for controlled in-vitro experiments to validate perfusion imaging methods such as Doppler and contrast-enhanced ultrasound (CEUS) imaging. In this work, acoustic properties of seven tissue-mimicking phantom materials at different concentrations of their compounds and five phantom case materials are characterized and compared at room temperature. The goal of this research is to determine the most suitable phantom and case material for ultrasound perfusion imaging experiments. The measurements show a wide range in speed of sound varying from 1057 to 1616 m/s, acoustic impedance varying from 1.09 to 1.71 x 10(6) kg/m(2) s, and attenuation coefficients varying from 0.1 to 22.18 dB/cm at frequencies varying from 1 MHz to 6 MHz for different phantom materials. The nonlinearity parameter B/A varies from 6.1 to 12.3 for most phantom materials. This work also reports the speed of sound, acoustic impedance and attenuation coefficient for case materials. According to our results, polyacrylamide (PAA) and polymethylpentene (TPX) are the optimal materials for phantoms and their cases, respectively. To demonstrate the performance of the optimal materials, we performed power Doppler ultrasound imaging of a perfusable phantom, and CEUS imaging of that phantom and a perfusion system. The obtained results can assist researchers in the selection of the most suited materials for in-vitro studies with ultrasound imaging. (C) 2021 The Author(s). Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.