EMOTIONAL MEMORY - IN SEARCH OF SYSTEMS AND SYNAPSES
EMOTIONAL MEMORY - IN SEARCH OF SYSTEMS AND SYNAPSES
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DOI：
10.1111/j.1749-6632.1993.tb17246.x
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发表时间：
1993-01-01
期刊：
影响因子：
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通讯作者：
LEDOUX, JE
中科院分区：
文献类型：
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作者：
LEDOUX, JE
对听觉刺激的自主神经和行为恐惧反应的基础神经系统现在有了更详细的了解。它涉及通过听觉系统投射到内侧膝状体，并从那里直接投射到杏仁核。外侧核是杏仁核的感觉接口，中央核是运动接口。外侧核通过基底外侧核间接投射到中央核。从杏仁中央核到中脑中央灰质的投射调节行为反应，而从杏仁中央核到下丘脑外侧核的投射调节自主神经反应。通过这种途径建立的情感记忆绕过了新大脑皮层，可能有助于无意识地处理情感。这样的记忆是不可磨灭的(高度抵抗灭绝)。感觉输入通路表现出长时间的突触增强，并似乎利用谷氨酸进行突触传递。杏仁外侧核中一种兴奋性氨基酸介导的突触可塑性可能是情绪学习的部分原因。
The neural system underlying the conditioning of autonomic and behavioral fear responses to auditory stimuli is now understood in some detail. It involves projections through the auditory system to the medial geniculate body and from there directly to the amygdala. The lateral nucleus is the sensory interface and the central nucleus the motor interface of the amygdala. The lateral nucleus projects to the central nucleus indirectly, by way of the basolateral nucleus. Projections from the amygdala central nucleus to the midbrain central gray region mediate the behavioral responses whereas projections from the amygdala central nucleus to the lateral hypothalamus mediate the autonomic responses. Emotional memories established through such pathways bypass the neocortex and may contribute to the unconscious processing of emotion. Such memories are indelible (highly resistant to extinction). The sensory input pathway exhibits long-term synaptic potentiation and appears to utilize glutamate in synaptic transmission. An excitatory amino acid-mediated form of synaptic plasticity in the lateral amygdala may be responsible in part for emotional learning.