2ND PROTEASOME-RELATED GENE IN THE HUMAN MHC CLASS-II REGION
2ND PROTEASOME-RELATED GENE IN THE HUMAN MHC CLASS-II REGION
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DOI：
10.1038/353667a0
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发表时间：
1991-10-17
期刊：
影响因子：
64.8
通讯作者：
TROWSDALE, J
中科院分区：
文献类型：
--
作者：
KELLY, A;POWIS, SH;TROWSDALE, J
抗原加工包括从细胞质蛋白产生肽并将其转运到内质网，在内质网中与主要组织相容性复合体（MHC） I类分子1-6结合。在MHC II类区域已经鉴定出两个基因，人类的RING4和RING11，它们被认为编码肽转运蛋白7-12。现在的注意力集中在转运蛋白是如何提供多肽的。蛋白酶体是一种具有多种蛋白水解活性的大型亚基复合体，是该功能的候选物13-16。最近，我们报道了一个蛋白酶体相关序列ring10在转运基因之间的定位。在这里，我们描述了第二个人类蛋白酶体样基因RING12， RING4位点立即着丝粒。因此，RING12、4、10和11在MHC内形成一个紧密相连的干扰素诱导基因簇，在抗原加工中发挥重要作用。
ANTIGEN processing involves the generation of peptides from cytosolic proteins and their transport into the endoplasmic reticulum where they associate with major histocompatibility complex (MHC) class I molecules 1-6. Two genes have been identified in the MHC class II region, RING4 and RING11 in humans, which are believed to encode the peptide transport proteins 7-12. Attention is now focused on how the transporters are provided with peptides. The proteasome, a large complex of subunits with multiple proteolytic activities, is a candidate for this function 13-16. Recently we reported a proteasome-related sequence, RING1O, mapping between the transporter genes 17. Here we describe a second human proteasome-like gene, RING12, immediately centromeric of the RING4 locus. Therefore RING12, 4, 10 and 11 form a tightly linked cluster of interferon-inducible genes within the MHC with an essential role in antigen processing.