Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis
Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis
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DOI：
10.1007/s10038-006-0405-6
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发表时间：
2006-06
影响因子：
3.5
通讯作者：
E. Zintzaras
中科院分区：
文献类型：
--
作者：
E. Zintzaras
To clarify the influence of MTHFR C677T and A1298C polymorphisms on gastric cancer (GC), a meta-analysis of eight case-control studies (1,584/2,785 cases/controls) was carried out. Overall, there was moderate heterogeneity among studies, and the C677T allele T was associated with a 27% increased risk of GC compared with C allele: the random effects (RE) OR (95% confidence interval in parenthesis) was significant [OR= 1.27 (1.13–1.44)]. In East Asians, the association was significant: RE OR= 1.28 (1.14–1.44), whereas, in Caucasians it was not significant. Regarding gastric cancer adenocarcinoma (GCA), an association for the allele contrast in East Asians was detected: fixed effects (FE) OR= 1.36 (1.18–1.56). The recessive model for allele T produced significant results overall and in East Asians for GC [FE OR= 1.47 (1.26–1.72) and FE OR= 1.61 (1.32–1.96), respectively] and for GCA [RE OR= 1.53 (1.13–2.05) and FE OR= 1.70 (1.36–2.12)]. The A1298C polymorphism was associated with GCA in East Asians: the FE OR for the allele contrast (C vs. A) was 1.38 (1.18–1.62), and under a recessive model for allele C, OR= 1.62 (1.28–2.06). There were no sources of bias in the selected studies; the differential magnitude of effect in large versus small studies was not significant. In conclusion, there is evidence of association between MTHFR polymorphisms and GC, mainly in East Asians.
