Progress towards the total synthesis of trichodermamides A and B: construction of the oxazine ring moiety.
Progress towards the total synthesis of trichodermamides A and B: construction of the oxazine ring moiety.
复制标题
木霉酰胺 A 和 B 的全合成进展：恶嗪环部分的构建。
作者：
Xiaobo Wan;G. Doridot;M. Joullié
木霉酰胺是一种具有独特的4h -5,6-二氢-1,2-恶嗪环的改性杂环二肽。从经济实惠，容易获得的(-)-奎宁酸开始，该恶嗪部分的对映选择性合成是通过分子内环氧化物开环反应实现的。[结构：见正文]
Trichodermamides are modified heterocyclic dipeptides that possess a unique 4H-5,6-dihydro-1,2-oxazine ring. Starting from affordable, easily available (-)-quinic acid, the enantioselective synthesis of this oxazine moiety was achieved by an intramolecular epoxide ring-opening reaction by an oxime. [structure: see text]