Minimal residual disease status determined by multiparametric flow cytometry pretransplantation predicts the outcome of patients with ALL receiving unmanipulated haploidentical allografts
Minimal residual disease status determined by multiparametric flow cytometry pretransplantation predicts the outcome of patients with ALL receiving unmanipulated haploidentical allografts
复制标题
移植前通过多参数流式细胞术确定的微小残留病状态可预测接受未经操作的半相合同种异体移植物的 ALL 患者的结果
DOI：
10.1002/ajh.25417
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发表时间：
2019-05-01
影响因子：
12.8
通讯作者：
Chang, Ying-Jun
中科院分区：
文献类型：
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作者：
Zhao, Xiao-Su;Liu, Yan-Rong;Chang, Ying-Jun
本研究评估了移植前微小残留病（pre-MRD）对接受未经操作的单倍相合干细胞移植（haplo-SCT）的急性淋巴细胞白血病（ALL）患者结局的影响。对543例ALL患者进行回顾性研究。使用多参数流式细胞术测定MRD。在MSDT环境中，无论是在整个患者队列还是在T-ALL或B-ALL亚组病例中，MRD前阳性患者的复发率（CIR）均高于MRD前阴性患者（P
This study evaluated the effects of pretransplantation minimal residual disease (pre-MRD) on outcomes of patients with acute lymphoblastic leukemia (ALL) who underwent unmanipulated haploidentical stem cell transplantation (haplo-SCT). A retrospective study including 543 patients with ALL was performed. MRD was determined using multiparametric flow cytometry. Both in the entire cohort of patients and in subgroup cases with T-ALL or B-ALL, patients with positive pre-MRD had a higher incidence of relapse (CIR) than those with negative pre-MRD in MSDT settings (P