The endoplasmic reticulum as a protein-folding compartment
The endoplasmic reticulum as a protein-folding compartment
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DOI：
10.1016/0962-8924(92)90309-b
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发表时间：
1992-01-01
影响因子：
19
通讯作者：
Braakman, Ineke
中科院分区：
文献类型：
--
作者：
Helenius, Ari;Marquardt, Thorsten;Braakman, Ineke
内质网（ER）的内腔为预定用于分泌的蛋白质的折叠以及各种细胞隔室和膜提供动态和有效的环境。通常，折叠过程在新生链上开始，并在寡聚体组装期间几分钟或几小时后完成。它由分子伴侣和折叠酶辅助，其中一些是ER所特有的。质量控制和选择性降解系统确保只有构象成熟的蛋白质从ER中转运。
The lumen of the endoplasmic reticulum (ER) provides a dynamic and efficient environment for the folding of proteins destined for secretion and for a variety of cellular compartments and membranes. Usually, the folding process begins on the nascent chains and is completed minutes or hours later during assembly of oligomers. It is assisted by molecular chaperones and folding enzymes, some of which are unique to the ER. Quality control and selective degradation systems ensure only conformationally mature proteins are transported from the ER.