Activation of angiogenesis differs strongly between pulmonary carcinoids and neuroendocrine carinomas and is crucial for carcinoid tumourgenesis.
Activation of angiogenesis differs strongly between pulmonary carcinoids and neuroendocrine carinomas and is crucial for carcinoid tumourgenesis.
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血管生成的激活在肺类癌和神经内分泌癌之间存在很大差异，并且对于类癌肿瘤的发生至关重要。
DOI：
10.7150/jca.9235
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发表时间：
2014
影响因子：
3.9
通讯作者：
Zarogoulidis P
中科院分区：
文献类型：
--
作者：
Mairinger FD;Walter RF;Werner R;Christoph DC;Ting S;Vollbrecht C;Zarogoulidis K;Huang H;Li Q;Schmid KW;Wohlschlaeger J;Zarogoulidis P
背景：肺癌仍然是继女性前列腺癌和乳腺癌之后男性癌症的主要原因。血管生成被认为是主要的微环境调节剂。材料和方法：人口统计数据和研究设计；该研究基于每种肿瘤实体（典型类癌、非典型类癌、大细胞神经内分泌癌、小细胞肺癌）的 20 个代表性标本，进行 mRNA 表达分析。进行了以下方法：RNA提取和RNA完整性评估、NanoString代码集设计和表达定量、NanoString数据处理和统计分析。结果：KDR 与肿瘤的侵袭性显着相关，并随着恶性肿瘤的增加而降低 (p=0.049)。 HIF1A 和 KDR mRNA 表达降低与肿瘤侵袭血管的风险较高相关（HIF1A：p=0.034；KDR：p=0.029）。 FigF 和 HIF1A 表达水平与无进展生存期显着相关（FIGF：p=0.021；HIF1A：p=0.049）。 CRHR2 和 FLT4 在女性患者中的表达强于男性患者（CRHR2：p=0.024，FLT4：p=0.004）。 FGF 表达在 LCNEC 和 SCLC 之间仍然显着 (p=0.023)。 FLT4 和 KDR 显示与分析组之一高度显着相关（FLT4：p=0.001；KDR：p=0.006）。此外，这些焦点群体之间的 HIF1A 表达存在显着差异 (p=0.018)。结论：临床应用时应考虑哪些因素对肿瘤生长和远端转移影响最大，进而研究易于给药、副作用低的药物。也许应该建立一个集群治疗系统，其中药物同时针对同一来源的不同途径。
Background: Lung cancer still remains the leading cause of cancer for men after prostate cancer and breast cancer for women. Angiogenesis is considered a major microenvironment modifier. Material and Methods: Demographic data and study design; The study is based on a collective of twenty representative specimens of each tumour entity (Typical Carcinoid, Atypical Carcinoid, Large-Cell Neuroendocrine Carcinoma , Small Cell Lung Cancer) for mRNA expression analysis. The following methods were performed: RNA Extraction and RNA Integrity Assessment, NanoString CodeSet Design and Expression Quantification, NanoString Data Processing and Statistical Analysis. Results: KDR rendered significant association to aggressiveness of the tumour and decreases with increasing malignancy (p=0.049). A decreased expression of HIF1A and KDR mRNA as associated with a higher risk of tumour invasion in vessels (HIF1A: p=0.034; KDR: p=0.029). FIGF and HIF1A expression levels are significantly associated with progression-free survival (FIGF: p= 0.021; HIF1A: p= 0.049). CRHR2 and FLT4 are stronger expressed in female than in male patients (CRHR2: p=0.024, FLT4: p=0.004). FIGF expression is still significant between LCNEC and SCLC (p=0.023). FLT4 and KDR show highly significant association to one of the analysed groups (FLT4: p=0.001; KDR: p=0.006). Additionally, HIF1A expression differs significantly between these focus cohorts (p=0.018). Conclusion: We should consider for clinical practice application which factors affect most the tumour growth and distal metastasis, thereafter investigate easy to administer drugs with low side effects. Probably a cluster system of therapy should be established where a drug targets simultaneously different pathways of the same origin.
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影响因子：
3.4
作者：
Garcia-Yuste, Mariano;Matilla, Jose M.;Muguruza, Ignacio
通讯作者：
Muguruza, Ignacio
影响因子：
9.6
作者：
Jett, JR;Midthun, DE
通讯作者：
Midthun, DE
DOI：
10.1007/s12032-014-0877-8
发表时间：
2014-04
期刊：
Medical oncology (Northwood, London, England)
影响因子：
--
作者：
Liu B;Liu Q;Song Y;Li X;Wang Y;Wan S;Zhang Z;Su H
通讯作者：
Su H
影响因子：
9.6
作者：
Fink, G;Krelbaum, T;Kramer, MR
通讯作者：
Kramer, MR
影响因子：
45.3
作者：
Natale, Ronald B.;Thongprasert, Sumitra;Goss, Glenwood D.
通讯作者：
Goss, Glenwood D.