Vascular endothelial growth factor and social support in patients with ovarian carcinoma
Vascular endothelial growth factor and social support in patients with ovarian carcinoma
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DOI：
10.1002/cncr.10739
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发表时间：
2002-08-15
期刊：
影响因子：
6.2
通讯作者：
Sood, AK
中科院分区：
文献类型：
--
作者：
Lutgendorf, SK;Johnsen, EL;Sood, AK
背景：行为因素（如压力、抑郁和社会支持）对与癌症相关的免疫活动的调节已被充分证明。然而，行为因素与参与肿瘤血管生成的细胞因子之间的关系尚未得到研究。血管内皮生长因子（VEGF）是一种能够刺激肿瘤血管生成的关键细胞因子，它与卵巢癌患者较差的生存率有关。VEGF受多种行为敏感因素的调节，包括交感神经激活。本研究探讨了术前卵巢癌患者的社会支持和抑郁症状与VEGF水平的关系。24名患有卵巢癌的女性和5名患有良性盆腔肿块的女性在术前就诊时被招募，接受了心理社会调查，包括癌症治疗的功能评估（生活质量）调查和情绪状态画像，并抽血。采用酶联免疫吸附法测定血清VEGF水平。分析控制了疾病分期。报告社会幸福感较高的卵巢癌妇女的VFGF水平较低（P = 0.005）。来自朋友和邻居的更多支持（P = 0.005）和与朋友的距离更短（P = 0.04）是与较低VEGF水平相关的社会幸福感方面。无助感（P = 0.03）或无价值感（P = 0.08）较高的个体VEGF水平较高，但整体抑郁与VEGF水平无关（P = 0.50）。卵巢癌术前患者较高的社会幸福感水平与较低的VEGF水平相关。这些发现提示了不良社会支持与疾病进展相关的可能机制。对这些关系的进一步研究可能会揭示生物行为因素与肿瘤生长和疾病进展的新途径。(C) 2002年美国癌症协会。
BACKGROUND, The modulation of immunologic activities relevant to cancer by behavioral factors, such as stress, depression, and social support, is well documented. However, associations of behavioral factors with cytokines involved in tumor angiogenesis have not been studied. Vascular endothelial growth factor (VEGF) is a key cytokine that is capable of stimulating tumor angiogenesis, and it has been associated with poorer survival in patients with ovarian carcinoma. VEGF is modulated by a variety of behaviorally sensitive factors, including sympathetic activation. This study examined relationships of social support and depressive symptoms with VEGF levels in preoperative patients with ovarian carcinoma.METHODS. Twenty-four women with ovarian carcinoma and 5 women with benign pelvic masses were recruited at the presurgical clinic visit, received psychosocial surveys, including the Functional Assessment of Cancer Therapy (Quality of Life) survey and the Profile of Mood States, and a blood draw. Serum VEGF levels were assessed by enzyme-linked immunosorbent assay. Analyses controlled for disease stage.RESULTS. Women with ovarian carcinoma who reported higher levels of social well being had lower levels of VFGF (P = 0.005). Greater support from friends and neighbors (P = 0.005) and less distance from friends (P = 0.04) were facets of social well being that were associated with lower VEGF levels. Individuals who reported greater helplessness (P = 0.03) or worthlessness (P = 0.08) had higher VEGF levels, but depression as a whole (P > 0.50) was not related to VEGF levels.CONCLUSIONS. Higher levels of social well being were correlated with lower VEGF levels in presurgical patients with ovarian carcinoma. These findings suggest a possible mechanism by which poor social support may be associated with disease progression. Further study of these relations may demonstrate novel pathways relating biobehavioral factors to tumor growth and disease progression. (C) 2002 American Cancer Society.