Pathophysiological correlates of thallium-201 myocardial uptake in experimental infarction.
Pathophysiological correlates of thallium-201 myocardial uptake in experimental infarction.
复制标题
实验性梗塞中铊 201 心肌摄取的病理生理学相关性。
作者：
V. Dicola;S. Downing;R. Donabedian;B. L. Zaret
在24小时龄的闭胸犬心肌梗死模型上，研究了心肌摄取Tl-201(201TI)的病理生理相关性。局部201Tl摄取的减少与组织肌酸磷酸激酶耗竭的大小和跨壁血流的微球估计值有很好的相关性。在低流量心内膜区，201Tl偶尔低估了血流减少的幅度。即使是轻微的201Tl摄取减少(低于正常的0.86)，也与组织病理学和组织化学证据有关。
The pathophysiological correlates of thallium-201 (201TI) myocardial uptake were studied in a 24-hour-old closed-chest canine infarct model. Reduction in regional 201Tl uptake correlated well with the magnitude of tissue creatine phosphokinase depletion and microsphere estimates of transmural blood flow. In low flow endocardial regions 201Tl occasionally under-estimated the magnitude of flow reduction. Even slight reductions of 201Tl uptake (less than 0.86 of normal) were associated with histopathological and histochemical evidence of necrosis.