Nutrition in pregnant or lactating rats programs lipid metabolism in the offspring
Nutrition in pregnant or lactating rats programs lipid metabolism in the offspring
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DOI：
10.1079/bjn19960066
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发表时间：
1996-10-01
影响因子：
3.6
通讯作者：
Hales, CN
中科院分区：
文献类型：
--
作者：
Lucas, A;Baker, BA;Hales, CN
人类流行病学研究表明，生命早期的体型与成年后的血液胆固醇浓度有关，提出了这样的假设：早期营养会影响后来的脂质代谢，从而影响后期血管疾病的风险。在这里，我们测试了大鼠怀孕或哺乳期间的营养会影响后代的脂质代谢的假设，并在成年期（平均 6 个月）进行了研究，将来自正常喂养的母鼠（对照）的大鼠 (n 35) 与来自母鼠的 (1) 只大鼠 (rr 22) 进行了比较妊娠期和哺乳期限制蛋白质摄入； (2) 正常喂养的母亲所生的大鼠 (n = 9) 与限制蛋白质的哺乳母鼠杂交，以及 (3) 那些 (n = 9) 由蛋白质限制的母鼠出生并与正常喂养的哺乳期动物杂交的大鼠，在后三组中，与对照组相比，后代的血浆胆固醇、高密度脂蛋白胆固醇和三酰甘油浓度长期降低，这种影响主要发生在雄性中，这些发现表明，在大鼠中，营养敏感期胆固醇和三酰甘油代谢的编程是在产前和产后（断奶前）进行的，并且大鼠可以通过在妊娠或哺乳期间改变母体营养环境来“间接”编程。虽然人们假设早期人类营养不良会增加患血管疾病的风险，但营养不良的一个方面是母体蛋白质摄入量低，在该大鼠模型中，血浆胆固醇和三酰甘油浓度较低。
Epidemiological studies in humans show that size in early life is related to blood cholesterol concentrations in adult Life, raising the hypothesis that early nutrition programs later lipid metabolism, affecting risk for later vascular disease, Here, we tested the hypothesis that nutrition during pregnancy or lactation in the rat programs lipid metabolism in the offspring, studied in adult life (mean 6 months), Rats (n 35) from normally-fed dams (controls) were compared with (1) rats (rr 22) from dams protein-restricted in pregnancy and lactation; (2) rats (n 9) born to normally-fed mothers crossed to protein-restricted lactating dams and (3) those (n 9) born of protein-restricted dams and crossed to normally-fed lactating animals, In these latter three groups the offspring showed long-term reduction in plasma cholesterol, HDL-cholesterol and triacylglycerol concentrations compared with controls, The effects were predominantly in males, These findings suggest that in the rat the sensitive period for nutritional programming of cholesterol and triacylglycerol metabolism is both pre- and postnatal (pre-weaning) and that rats may be 'indirectly' programmed by altering the maternal nutritional milieu during gestation or lactation. Whilst it has been hypothesized that early human undernutrition programs risk for vascular disease, one aspect of undernutrition, low maternal protein intake, in this rat model programmed lower plasma cholesterol and triacylglycerol concentrations.