Tumor budding in intestinal-type gastric adenocarcinoma is associated with nodal metastasis and recurrence
Tumor budding in intestinal-type gastric adenocarcinoma is associated with nodal metastasis and recurrence
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DOI：
10.1016/j.humpath.2017.03.021
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发表时间：
2017-10-01
期刊：
影响因子：
3.3
通讯作者：
Nalbantoglu, ILKe
中科院分区：
文献类型：
--
作者：
Olsen, Stephen;Jin, Linda;Nalbantoglu, ILKe
胃腺癌（GAC）是全球癌症相关死亡的常见原因。GAC可分为肠道型和弥漫型。肠型癌症是常见的，据报道与弥漫性癌症相比具有更好的预后。研究表明，结肠和食管的肠癌中肿瘤出芽的存在和数量可以预测淋巴结转移和复发。我们的目的是确定肿瘤出芽在卵巢型GAC与预后特征相关。1999年至2013年间，确定了104名接受初次手术切除治疗的患者。组织学类型（肠道，弥漫性，或混合），肿瘤分级，T分期，淋巴结状态进行了评价。使用先前描述的结直肠腺癌的方法，将肿瘤芽评分分配给所有直肠型癌症。得分= 1为高。肿瘤特征如下：52例肠型（50%），36例弥漫型（35%），16例混合型（15%）。在52例肠组织学检查中，4例（8%）为高分化，28例（54%）为中等分化，20例（38%）为低分化。33例（63%）肠肿瘤的肿瘤芽评分较高。得分高的病例与较高的T分期、N分期和分级相关（P <0.001，P <0.001和P = 0.002）。这些也有较高的复发可能性（P = 0.007）。在我们的队列研究中，卵巢型GAC的高肿瘤芽评分具有较高的T分期、N分期、分级和复发可能性。评估肿瘤萌芽可能指导临床管理的一个子集的患者。(C)2017爱思唯尔公司All rights reserved.
Gastric adenocarcinoma (GAC) is a common cause of cancer-related death worldwide. GAC can be classified as intestinal or diffuse. Intestinal-type cancers are common and reported to have a better prognosis compared to diffuse cancers. Studies have shown the presence and amount of tumor budding in intestinal carcinomas of the colon and esophagus to predict nodal metastasis and recurrence. Our aim is to determine if tumor budding in intestinal-type GAC correlates with prognostic features. One hundred four patients treated with primary surgical excision between 1999 and 2013 were identified. Histologic type (intestinal, diffuse, or mixed), tumor grade, T-stage, and lymph node status were evaluated. Tumor bud scores were assigned to all intestinal-type cancers using methods previously described for colorectal adenocarcinoma. Scores of = 1 as high. Tumor characteristics were as follows: 52 intestinal (50%), 36 diffuse (35%), and 16 mixed (15%). Of the 52 cases with intestinal histology, 4 were well (8%), 28 were moderately (54%), and 20 were poorly differentiated (38%). Thirty-three (63%) of the intestinal tumors had high tumor bud scores. Cases with high scores were associated with higher T-stage, N-stage, and grade (P < .001, P < .001, and P = .002). These also had a higher likelihood of recurrence (P = .007). In our cohort, high tumor bud scores in intestinal-type GAC have higher T-stage, N-stage, grade, and likelihood of recurrence. Assessment of tumor budding may guide clinical management in a subset of patients. (C) 2017 Elsevier Inc. All rights reserved.