A new neuroinformatics approach to personalized medicine in neurology: The Virtual Brain.
A new neuroinformatics approach to personalized medicine in neurology: The Virtual Brain.
复制标题
DOI：
10.1097/wco.0000000000000344
复制
发表时间：
2016-08
影响因子：
4.8
通讯作者：
Solodkin A
中科院分区：
文献类型：
--
作者：
Falcon MI;Jirsa V;Solodkin A
神经成像领域的一个令人兴奋的进展是获取和处理非常大的数据集（所谓的“大数据”），允许大规模推论，促进对健康和疾病中的大脑功能的更好理解。然而，我们显然缺乏的是量化的综合工具，将这种理解转化为个人层面，为个性化医疗奠定基础。在这里，我们通过回顾相对较新的神经信息学建模领域如何能够在从微观到宏观，从局部到分布的不同探究水平上跟踪大脑网络功能来解决这一挑战。在此背景下，我们引入了一种新的独特的多尺度方法，即虚拟脑（TVB），它有效地模拟了个性化的大脑活动，将大尺度（宏观）大脑动力学与微观层面的生物物理参数联系起来。我们还展示了TVB模型如何在癫痫和中风中提供独特的生物学解释数据。这些结果为有意地将计算生物学和神经科学整合到阐明疾病细胞机制的临床方法中奠定了基础。在未来，这可以提供一种方法来创建一个特定疾病模型的集合，这些模型可以在个人层面上应用于个性化的治疗干预。http://links.lww.com/CONR/A41
An exciting advance in the field of neuroimaging is the acquisition and processing of very large data sets (so called ‘big data’), permitting large-scale inferences that foster a greater understanding of brain function in health and disease. Yet what we are clearly lacking are quantitative integrative tools to translate this understanding to the individual level to lay the basis for personalized medicine. Here we address this challenge through a review on how the relatively new field of neuroinformatics modeling has the capacity to track brain network function at different levels of inquiry, from microscopic to macroscopic and from the localized to the distributed. In this context, we introduce a new and unique multiscale approach, The Virtual Brain (TVB), that effectively models individualized brain activity, linking large-scale (macroscopic) brain dynamics with biophysical parameters at the microscopic level. We also show how TVB modeling provides unique biological interpretable data in epilepsy and stroke. These results establish the basis for a deliberate integration of computational biology and neuroscience into clinical approaches for elucidating cellular mechanisms of disease. In the future, this can provide the means to create a collection of disease-specific models that can be applied on the individual level to personalize therapeutic interventions. http://links.lww.com/CONR/A41