Visible-absorption spectroscopy as a biomarker to predict treatment response and prognosis of surgically resected esophageal cancer.
Visible-absorption spectroscopy as a biomarker to predict treatment response and prognosis of surgically resected esophageal cancer.
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DOI：
10.1038/srep33414
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发表时间：
2016-09-14
影响因子：
4.6
通讯作者：
Lee JM
中科院分区：
文献类型：
--
作者：
Yang PW;Hsu IJ;Chang CW;Wang YC;Hsieh CY;Shih KH;Wong LF;Shih NY;Hsieh MS;Hou MT;Lee JM
光吸收光谱在预后预测中的应用几乎没有研究。我们开发和评估了一种新的二维吸收光谱测量系统(TDAS)，用于早期诊断、评估对化疗的反应和做出预后预测。用TDAS对120例食管癌患者的正常组织和肿瘤组织的体外吸收光谱进行了分析。我们展示了癌组织，来自同步放化疗(CCRT)反应差的患者的组织，以及来自早期疾病进展的患者的组织，每个组织都有一个容易识别的共同光谱特征。主成分分析(PCA)将组织光谱划分为不同的组，证明了利用吸收光谱区分正常组织和肿瘤组织，以及预测CCRT反应、不良生存和肿瘤复发(效率分别为75%、100%和85.7%)的可行性。多因素分析显示，不良反应、不良生存和复发谱特征分别与慢性肾移植不良反应风险增加(P = 0.012)、死亡风险增加(P = 0.111)和复发风险增加(P = 0.030)相关。我们的研究结果表明，光学吸收显微镜在食道癌的术前诊断和预后预测方面具有很大的潜力。
The application of optical absorption spectra in prognostic prediction has hardly been investigated. We developed and evaluated a novel two dimensional absorption spectrum measurement system (TDAS) for use in early diagnosis, evaluating response to chemoradiation, and making prognostic prediction. The absorption spectra of 120 sets of normal and tumor tissues from esophageal cancer patients were analyzed with TDAS ex-vivo. We demonstrated the cancerous tissue, the tissue from patients with a poor concurrent chemoradiotherapy (CCRT) response, and the tissue from patients with an early disease progression each had a readily identifiable common spectral signature. Principal component analysis (PCA) classified tissue spectra into distinct groups, demonstrating the feasibility of using absorption spectra in differentiating normal and tumor tissues, and in predicting CCRT response, poor survival and tumor recurrence (efficiencies of 75%, 100% and 85.7% respectively). Multivariate analysis revealed that patients identified as having poor-response, poor-survival and recurrence spectral signatures were correlated with increased risk of poor response to CCRT (P = 0.012), increased risk of death (P = 0.111) and increased risk of recurrence (P = 0.030) respectively. Our findings suggest that optical absorption microscopy has great potential to be a useful tool for pre-operative diagnosis and prognostic prediction of esophageal cancer.
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影响因子：
6.2
作者：
Abrams, Julian A.;Buono, Donna L.;Strauss, Joshua;McBride, Russell B.;Hershman, Dawn L.;Neugut, Alfred I.
通讯作者：
Neugut, Alfred I.
影响因子：
4.6
作者：
Hsu, Po-Kuei;Wu, Yu-Chung;Hsu, Wen-Hu
通讯作者：
Hsu, Wen-Hu
影响因子：
5.7
作者：
Matsuyama, T;Nakanishi, K;Maehara, T
通讯作者：
Maehara, T
影响因子：
158.5
作者：
Kelsen, DP;Ginsberg, R;Roth, JA
通讯作者：
Roth, JA
影响因子：
45.3
作者：
Allum, William H.;Stenning, Sally P.;Langley, Ruth E.
通讯作者：
Langley, Ruth E.