Utility of the HIV Dementia Scale (HDS) in identifying HIV dementia in a South African sample
Utility of the HIV Dementia Scale (HDS) in identifying HIV dementia in a South African sample
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DOI：
10.1016/j.jns.2007.12.027
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发表时间：
2008-06-15
影响因子：
4.4
通讯作者：
Stein, D.
中科院分区：
文献类型：
--
作者：
Ganasen, K. A.;Fincham, D.;Stein, D.
背景：简易精神状态检查 (MMSE) 传统上用于筛查各种痴呆症中的认知障碍，包括 HIV 相关痴呆。最近，HIV 痴呆量表 (HDS) 被开发为一种床旁评估测试，用于区分 HIV 相关性痴呆患者和认知正常的患者。 目的：本研究以南非开普敦都会区接受抗逆转录病毒 (ARV) 服务的 474 名患者为样本，评估了 HDS 的敏感性和特异性（使用 MMSE 作为金标准）。根据病历审查，这些患者均没有预先存在的痴呆症临床诊断。结果：HDS 和 MMSE 显着相关，并且表现出显着一致性。尽管如此，HDS 发现比 MMSE 表现出认知障碍的参与者更多。 ROC 曲线分析显示，HDS 截止值：5 × 10 的敏感性为 80%，特异性为 80%，并且在 90% 的时间内区分是否存在认知障碍。结论：我们的研究结果表明，HDS 可能是接受 ARV 服务的患者中 HIV 相关痴呆的更敏感的筛查工具。 (C) 2008 Elsevier B.V. 保留所有权利。
Background: The Mini Mental State Examination (MMSE) has been traditionally used to screen for cognitive impairment in a variety of dementing illnesses, including HIV associated dementia. More recently, the HIV Dementia Scale (HDS) was developed as a bedside evaluation test to differentiate patients with HIV-associated frank dementia from those who are cognitively normal.Objective: This study assessed the sensitivity and specificity of the HDS (using the MMSE as the gold standard) in a sample of 474 patients attending anti-retroviral (ARV) services in the Cape Town metropole of South Africa. None of these patients had a pre-existing clinical diagnosis of dementia based on a review of the medical records.Results: The HDS and MMSE were significantly correlated and showed significant agreement. Nonetheless, the HDS identified more participants demonstrating cognitive impairment than the MMSE. An ROC curve analysis revealed that an HDS cut-off of :5 10 yielded a sensitivity of 80%, specificity of 80%, and discriminated between the presence and absence of cognitive impairment 90% of the time.Conclusion: Our findings suggest that the HDS may be a more sensitive screening instrument for HIV associated dementia in patients attending ARV services. (C) 2008 Elsevier B.V. All rights reserved.