Myocardial perfusion imaging with 99mTc-DMPE in man.
Myocardial perfusion imaging with 99mTc-DMPE in man.
复制标题
使用 99mTc-DMPE 对人体进行心肌灌注成像。
DOI：
10.1007/bf00253208
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Williams,CC
中科院分区：
文献类型：
--
作者：
Gerson,MC;Deutsch,EA;Nishiyama,H;Libson,KF;Adolph,RJ;Grossman,LW;Sodd,VJ;Fortman,DL;Vanderheyden,JL;Williams,CC
99 mTc-DMPE（99 mTc-DMPE）是一种新合成的心肌灌注显像剂。在本研究中，在四个人类受试者中评估了该药剂的剂量测定和潜在临床用途。吸收的辐射剂量较低，胆囊的最高剂量为200 mrad/mCi（54 μ戈伊/MBq），肝脏的最高剂量为160 mrad/mCi（43 μ戈伊/MBq）。没有发现临床毒性的证据。锝-99mDMPE确实对心肌成像，但靶向与非靶向活性的比率不如在狗中观察到的有利。强烈的肝99 mTc-DMPE活动干扰的心尖的临床成像的四个科目中的两个。我们的结论是，原型放射性药物，99 mTc-DMPE，是能够在人体心肌灌注显像，但平面心肌图像的质量较差相比，201 Tl心肌图像。进一步的工作是合理的，以开发相关化合物，以克服所描述的临床局限性。
Technetium-99m DMPE (99mTc-DMPE) is a newly synthesized myocardial perfusion imaging agent that shows intense myocardial accumulation in the dog. In the present study, dosimetry and potential clinical usefulness of this agent were assessed in four human subjects. Absorbed radiation doses were low, with the highest doses consisting of 200 mrad/mCi (54 μGy/MBq) to the gallbladder and 160 mrad/mCi (43 μGy/MBq) to the liver. No evidence of clinical toxicity was found. Technetium-99m DMPE did image the myocardium, but the ratio of target to nontarget activity was less favorable than that observed in the dog. Intense hepatic99mTc-DMPE activity interfered with clinical imaging of the cardiac apex in two of the four subjects. We conclude that the prototype radiopharmaceutical,99mTc-DMPE, is capable of myocardial perfusion imaging in man but the planar myocardial images produced are of inferior quality compared with201Tl myocardial images. Further work is justified to develop related compounds to overcome the clinical limitations described.