A proton-responsive ensemble using mesocellular foam supports capped with N, O-carboxymethyl chitosan for controlled release of bioactive proteins
A proton-responsive ensemble using mesocellular foam supports capped with N, O-carboxymethyl chitosan for controlled release of bioactive proteins
复制标题
使用中孔泡沫支撑的质子响应整体，其上覆盖有 N, O-羧甲基壳聚糖，用于控制生物活性蛋白质的释放
DOI：
10.1039/c5tb00219b
复制
发表时间：
2015-01-01
影响因子：
7
通讯作者：
Liu, Changsheng
中科院分区：
文献类型：
--
作者：
Gan, Qi;Zhu, Jiaoyang;Liu, Changsheng
通过GPTMS交联水溶性N，O-羧甲基壳聚糖，制备了一种新型pH响应性介孔泡沫纳米载体。递送系统显示出优异的蛋白质负载，在酸性环境中具有可编程释放。此外，释放的蛋白质仍然保持其构象和生物活性。
A novel pH-responsive mesocellular foam-based nanocarrier was fabricated by the covalent assembly of a water-soluble N, O-carboxymethyl chitosan via the crosslinking of GPTMS. The delivery systems show excellent protein loading with programmable release in an acid environment. Moreover, the released proteins still preserve their conformational and biological activity.