Plexiform granular cell tumor. A report of two cases.
Plexiform granular cell tumor. A report of two cases.
复制标题
丛状颗粒细胞瘤。
DOI：
10.1097/00000372-199410000-00016
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
J. Farber
中科院分区：
文献类型：
--
作者：
J. Lee;J. Bhawan;F. Wax;J. Farber
在一名10岁女孩的小腿和一名12岁女孩的背部发现了一种先前未被描述的具有有趣的丛状模式的颗粒细胞肿瘤变体。临床上，患者表现为皮内斑块，并伴有不同程度的疼痛或压痛。组织病理学检查显示颗粒细胞肿瘤，具有不同大小的束状结构，特别是在神经束周围，呈丛状。胞质颗粒PAS阳性。免疫组化研究显示肿瘤细胞S-100蛋白强阳性，α -1抗凝乳胰蛋白酶和vimentin弱阳性。这些发现进一步支持颗粒细胞瘤的神经起源。
A previously undescribed variant of granular cell tumor with an interesting plexiform pattern was found in the lower leg of a 10-year-old girl and on the back of a 12-year-old girl. Clinically, the patients presented with intradermal plaques that were accompanied by variable degrees of pain or tenderness. Histopathologic examination revealed granular cell tumors with various sized fascicles, particularly around nerve bundles, in a plexiform pattern. Cytoplasmic granules were PAS positive. Immunohistochemical studies showed tumor cells to be strongly positive with S-100 protein and weakly positive with alpha-1-antichymotrypsin and vimentin. These findings offer further support for a neural origin for granular cell tumors.