Development of a Mouse Biomagnetic Measurement System by Using a High-TC SQUID Magnetometer
Development of a Mouse Biomagnetic Measurement System by Using a High-TC SQUID Magnetometer
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DOI：
10.1109/tasc.2010.2094993
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发表时间：
2011-06-01
影响因子：
1.8
通讯作者：
Lee, Yong-Ho
中科院分区：
文献类型：
--
作者：
Kim, In-Seon;Ahn, San;Lee, Yong-Ho
我们利用高T-C SQUID磁力计开发了小鼠生物磁测量系统。该系统由高T-C SQUID磁力计、台式磁屏蔽盒和温冷距离约为4毫米的非磁性杜瓦瓶组成。将重量约27g的小鼠麻醉并以仰卧位固定在屏蔽箱内的塑料xyz平台上。 SQUID 读出信号被数字化为 24 位，并以 1280 Hz 的采样率记录。我们通过改变屏蔽箱内对象的 x 和 y 位置来进行扫描测量。最后，我们可以获得峰值约为 20 pT 的清晰小鼠 MCG 波形，具有明确的 P 波、QRS 波和 T 波。我们证明了基于高 T-C SQUID 磁力计的生物磁测量系统可用于监测具有足够信噪比的小鼠 MCG 信号。
We have developed a biomagnetic measurement system for mouse by using high-T-C SQUID magnetometer. The system consists of a high-T-C SQUID magnetometer, a table-top magnetically shielded box, and a nonmagnetic dewar with a warm-to-cool distance of about 4 mm. Mice with weights of about 27 g were anesthetized and fixed in supine position on a plastic xyz-stage inside the shield box. The SQUID readout signal was digitized in 24-bit and recorded with sampling rate of 1280 Hz. We carried out a scanning measurement by changing x-and y-position of the subject inside the shield box. Finally, we could obtain clear mouse MCG waveforms of about 20 pT in peak amplitude with well defined P-, QRS-, and T-wave. We demonstrated the high-T-C SQUID magnetometer based biomagnetic measurement system is useful for monitoring mouse MCG signals with sufficient noise-to-signal ratio.