Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study
Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study
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DOI：
10.3109/09513590.2010.540600
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发表时间：
2011-10-01
影响因子：
2
通讯作者：
Youssef, M. Af.
中科院分区：
文献类型：
--
作者：
Khattab, S.;Mohsen, I. A.;Youssef, M. Af.
背景。患有多囊卵巢综合症（PCOS）的女性患妊娠糖尿病（GDM）的风险很高。我们假设二甲双胍由于其代谢、内分泌、血管和抗炎作用可能会降低 PCOS 女性 GDM 的发病率。患者和方法。我们进行了一项前瞻性队列研究，以确定二甲双胍对 PCOS 患者怀孕期间的有益影响。纳入了 360 名非糖尿病 PCOS 患者，她们通过不同的治疗方式接受二甲双胍怀孕。 200 名孕妇在整个怀孕期间继续服用二甲双胍，剂量为每天 1000-2000 毫克（研究组），160 名妇女在受孕时停止使用二甲双胍（对照组）。结果。二甲双胍组 GDM 发生率显着降低（OR：0.17，95% CI：0.07-0.37）。二甲双胍组先兆子痫的发生率在统计学上显着降低（OR：0.35，95% CI：0.13-0.94）。结论。二甲双胍是一种很有前途的药物，可用于预防或减少多囊卵巢综合症女性 GDM 和先兆子痫的发生率。
Background. Women with polycystic ovary syndrome (PCOS) are at a high risk to develop Gestational Diabetes mellitus (GDM). We hypothesized that metformin due to its metabolic, endocrine, vascular, and anti-inflammatory effects may reduce the incidence of GDM in PCOS women.Patient and method. We carried out a prospective cohort study to determine the beneficial effects of metformin on PCOS patients during pregnancy. Three-hundred and sixty non-diabetic PCOS patients were included who were conceived on metformin by different treatment modalities. Two-hundred pregnant women continued on metformin at a dose of 1000-2000 mg daily throughout pregnancy (study group) and 160 women discontinued metformin use at the time of conception (control group).Results. There is a statistically significant reduction in the incidence of GDM in favor of metformin group (OR: 0.17, 95% CI: 0.07-0.37). There is a statistically significant reduction in the incidence of pre-eclampsia in favor of metformin group (OR: 0.35, 95% CI: 0.13-0.94).Conclusion. Metformin is a promising medication for the prevention or reduction of the incidence of GDM and pre-eclampsia in PCOS women.