Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update.
Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update.
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DOI：
10.1007/s00401-009-0612-2
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发表时间：
2010-01
影响因子：
12.7
通讯作者：
Mann DM
中科院分区：
文献类型：
--
作者：
Mackenzie IR;Neumann M;Bigio EH;Cairns NJ;Alafuzoff I;Kril J;Kovacs GG;Ghetti B;Halliday G;Holm IE;Ince PG;Kamphorst W;Revesz T;Rozemuller AJ;Kumar-Singh S;Akiyama H;Baborie A;Spina S;Dickson DW;Trojanowski JQ;Mann DM
一年前，我们在该杂志上发表了一个推荐的额颞叶变性（FTLD）神经病理亚型命名法[7]。这背后的一个主要动力是解决围绕使用术语“FTLD与泛素化包涵体”（FTLD-U）出现的混淆，发现这些病例的分子病理学是异质性的，其中大多数但不是全部以病理性TDP-43为特征[6，11]。此外，还引入了一个疾病分类系统，根据目前的证据，根据最具特征的分子缺陷，将FTLD亚型分为几大类。这一系统提供了一个简明一致的术语，现已在文献中广泛采用。另一个预期的优势是能够随时适应新的发现。当时，我们没有预料到这个属性会多快地投入使用。尽管大多数FTLD的特征在于由tau（FTLD-tau）或TDP-43（FTLD-TDP）组成的细胞包涵体，但大约10-15%的病例
One year ago, in this journal, we published a recommended nomenclature for the neuropathologic subtypes of frontotemporal lobar degeneration (FTLD)[7]. A major impetus behind this was to resolve the confusion that had arisen around the use of the term ‘‘FTLD with ubiquitinated inclusions’’(FTLD-U), following the discovery that the molecular pathology of these cases was heterogeneous, with most, but not all, being characterized by pathological TDP-43 [6, 11]. In addition, a system of nosology was introduced that grouped the FTLD subtypes into broad categories, based on the molecular defect that is most characteristic, according to current evidence. This system provided a concise and consistent terminology that has now been widely adopted in the literature. Another anticipated advantage was the ability to readily accommodate new discoveries. At the time, we did not anticipate how quickly this attribute would be put to use. Although most FTLDs are characterized by cellular inclusion bodies composed of either tau (FTLD-tau) or TDP-43 (FTLD-TDP), approximately 10–15% of cases
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影响因子：
56.9
作者：
Kwiatkowski, T. J., Jr.;Bosco, D. A.;Brown, R. H., Jr.
通讯作者：
Brown, R. H., Jr.
影响因子：
14.5
作者：
Neumann, Manuela;Rademakers, Rosa;Mackenzie, Ian R. A.
通讯作者：
Mackenzie, Ian R. A.
影响因子：
12.7
作者：
Neumann M;Roeber S;Kretzschmar HA;Rademakers R;Baker M;Mackenzie IR
通讯作者：
Mackenzie IR
影响因子：
8.6
作者：
Kovacs, Gabor G.;Murrell, Jill R.;Spina, Salvatore
通讯作者：
Spina, Salvatore
影响因子：
12.7
作者：
Cairns, NJ;Uryu, K;Trojanowski, JQ
通讯作者：
Trojanowski, JQ