How to Improve the Survival of Transplanted Mesenchymal Stem Cell in Ischemic Heart?
How to Improve the Survival of Transplanted Mesenchymal Stem Cell in Ischemic Heart?
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如何提高移植间充质干细胞在缺血心脏中的存活率？
DOI：
10.1155/2016/9682757
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发表时间：
2016
影响因子：
4.3
通讯作者：
Zeng C
中科院分区：
文献类型：
--
作者：
Li L;Chen X;Wang WE;Zeng C
间充质干细胞(MSC)是目前研究较多的用于心脏修复的干细胞类型。几十年来，动物模型的临床前研究和临床试验表明，骨髓间充质干细胞移植对缺血性心脏病有一定的治疗作用。然而，仍然有主要的局限性需要克服，其中之一是心脏组织移植后的存活率非常低。人们尝试了各种策略来提高MSC的存活率，其中许多策略都取得了令人振奋的结果。在这篇综述中，我们分析了近年来的研究，总结了解决这一问题的新策略的方法、效果和机制。
Mesenchymal stem cell (MSC) is an intensely studied stem cell type applied for cardiac repair. For decades, the preclinical researches on animal model and clinical trials have suggested that MSC transplantation exerts therapeutic effect on ischemic heart disease. However, there remain major limitations to be overcome, one of which is the very low survival rate after transplantation in heart tissue. Various strategies have been tried to improve the MSC survival, and many of them showed promising results. In this review, we analyzed the studies in recent years to summarize the methods, effects, and mechanisms of the new strategies to address this question.