Comparisons of ATP turnover in human muscle during ischemic and aerobic exercise using 31P magnetic resonance spectroscopy

Comparisons of ATP turnover in human muscle during ischemic and aerobic exercise using 31P magnetic resonance spectroscopy
复制标题

使用 31P 磁共振波谱比较缺血和有氧运动期间人体肌肉 ATP 转换

DOI:
--
复制
发表时间:
1994
影响因子:
3.3
通讯作者:
G. Radda
G. Radda
中科院分区:
医学3区
文献类型:
--
作者:
G. Kemp;C. Thompson;P. Barnes;P. Barnes;G. Radda

文献摘要

参考文献

被引文献

相似文献

为了研究人体肌肉生物能量学定量在体内,我们使用31 P磁共振波谱研究屈趾浅肌的四个成年男性在动态缺血和有氧运动在0.50-1.00 W和恢复期间从有氧运动。在运动过程中,pH和[PCr]的变化在较高功率下较大,但在有氧运动中,运动结束[ADP]和运动后初始PCr再合成率均不随功率变化。在缺血性运动中,我们估计总ATP的合成率的PCr消耗和糖原分解(推断使用质子缓冲分析),这是线性的功率输出。在有氧运动中,我们再次估计了由于磷酸肌酸水解和糖原分解(包括质子流出校正)引起的ATP合成率,并使用缺血性运动期间建立的总ATP周转率通过差异估计了氧化ATP合成。我们的结论是,在早期运动的氧化ATP合成是小的,增加运动结束时的值接近(如预测)的初始postexercise率的PCr再合成。此外,从恢复过程中质子流出的pH依赖性可以推断出有氧运动期间质子流出的合理估计。
To investigate human muscle bioenergetics quantitatively in vivo, we used 31P magnetic resonance spectroscopy to study the flexor digitorum superficialis of four adult males during dynamic ischemic and aerobic exercise at 0.50–1.00 W and during recovery from aerobic exercise. During exercise, changes in pH and [PCr] were larger at higher power, but in aerobic exercise neither end‐exercise [ADP] nor the initial postexercise PCr resynthesis rate altered with power. In ischemic exercise we estimated total ATP synthesis from the rates of PCr depletion and glycogenolysis (inferred using an analysis of proton buffering); this was linear with power output. In aerobic exercise, again we estimated ATP synthesis rates due to phosphocreatine hydrolysis and glycogenolysis (incorporating a correction for proton efflux) and also estimated oxidative ATP synthesis by difference, using the total ATP turnover rate established during ischemic exercise. We conclude that in early exercise oxidative ATP synthesis was small, increasing by the end of exercise to a value close (as predicted) to the initial postexercise rate of PCr resynthesis. Furthermore, a plausible estimate of proton efflux during aerobic exercise can be inferred from the pH‐dependence of proton efflux in recovery.
有氧代谢的简单模型:在肌肉工作转换中的应用。
DOI: 10.1152/ajpcell.1990.258.6.c995
发表时间: 1990
期刊: The American journal of physiology
影响因子: --
作者:
Funk,CI;ClarkJr,A;Connett,RJ
通讯作者: Connett,RJ
DOI: 10.1161/01.cir.80.6.1668
发表时间: 1989-12-01
期刊: CIRCULATION
影响因子: 37.8
作者:
WILSON, JR;MANCINI, DM;CHANCE, B
通讯作者: CHANCE, B
红肌摄氧量的调节:当前的生化假设是否符合体内数据?
DOI: 10.1152/ajpregu.1989.256.4.r898
发表时间: 1989
期刊: The American journal of physiology
影响因子: --
作者:
Connett,RJ;Honig,CR
通讯作者: Honig,CR