Relationship between Platelet PPARs, cAMP Levels, and P-Selectin Expression: Antiplatelet Activity of Natural Products.
Relationship between Platelet PPARs, cAMP Levels, and P-Selectin Expression: Antiplatelet Activity of Natural Products.
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DOI：
10.1155/2013/861786
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Palomo I
中科院分区：
文献类型：
--
作者：
Fuentes E;Palomo I
血小板不再被简单地视为参与血栓形成的细胞。在动脉粥样硬化中，血小板是多个过程的调节者，通过向病变部位募集炎症细胞，释放炎症介质，调节内皮功能。长期以来，抗血小板治疗一直被用于预防和治疗心血管疾病。然而，一些患者的疗效有限、耐药性和副作用是目前抗血小板治疗的局限性。在此背景下，大量的天然产物(多酚、萜类、生物碱和脂肪酸)已被报道具有抗血小板活性。从这个意义上讲，本文阐述了天然产物通过cAMP水平抑制血小板P-选择素表达的机制及其作为过氧化体增殖物激活受体激动剂的作用。
Platelets are no longer considered simply as cells participating in thrombosis. In atherosclerosis, platelets are regulators of multiple processes, with the recruitment of inflammatory cells towards the lesion sites, inflammatory mediators release, and regulation of endothelial function. The antiplatelet therapy has been used for a long time in an effort to prevent and treat cardiovascular diseases. However, limited efficacy in some patients, drug resistance, and side effects are limitations of current antiplatelet therapy. In this context, a large number of natural products (polyphenols, terpenoids, alkaloids, and fatty acids) have been reported with antiplatelet activity. In this sense, the present paper describes mechanisms of antiplatelet action of natural products on platelet P-selectin expression through cAMP levels and its role as peroxisome proliferator-activated receptors agonists.
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影响因子：
6.7
作者：
Chuang, Wen-Ying;Kung, Po-Hsiung;Wu, Chin-Chung
通讯作者：
Wu, Chin-Chung
影响因子：
6.1
作者：
Cavagnaro, Pablo F.;Camargo, Alejandra;Simon, Philipp W.
通讯作者：
Simon, Philipp W.
影响因子：
6.1
作者：
Chou, Tz-Chong;Shih, Ching-Yu;Chen, Ying-Tsung
通讯作者：
Chen, Ying-Tsung
DOI：
10.1161/atvbaha.108.183160
发表时间：
2009-05-01
影响因子：
8.7
作者：
Ali, Ferhana Y.;Armstrong, Paul C. J.;Warner, Timothy D.
通讯作者：
Warner, Timothy D.
影响因子：
7.3
作者：
Chang, M. C.;Uang, B. J.;Jeng, J. H.
通讯作者：
Jeng, J. H.