Incidence of Breast, Prostate, Testicular, and Thyroid Cancer in Italian Contaminated Sites with Presence of Substances with Endocrine Disrupting Properties.
Incidence of Breast, Prostate, Testicular, and Thyroid Cancer in Italian Contaminated Sites with Presence of Substances with Endocrine Disrupting Properties.
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DOI：
10.3390/ijerph14040355
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发表时间：
2017-03-29
影响因子：
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通讯作者：
Comba P
中科院分区：
文献类型：
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作者：
Benedetti M;Zona A;Beccaloni E;Carere M;Comba P
本研究的目的是调查乳腺癌（女性），前列腺癌，睾丸癌和甲状腺癌的发病率在意大利国家优先污染的网站（NPCSs），癌症登记处，其中存在的内分泌干扰物（ED），报告与这些肿瘤，记录。根据国际科学机构和委员会的评价，对NPCS中存在的ED致癌性证据进行了评估。计算1996年至2005年期间每个NPCS和癌症部位的标准化发病率比率（SIR）。在14个NPC中有12个发现了一个或多个癌症部位的过度发生。在8个NPC中发现乳腺癌的SIR显著增加，6个NPC中发现前列腺癌的SIR显著增加，4个NPC中发现甲状腺癌（两种性别）的SIR显著增加，2个NPC中发现睾丸癌的SIR显著增加。在5例睾丸癌NPCS和2例甲状腺癌NPCS（男性）中发现SIRS无显着增加。在少数情况下，报告了显着的缺陷，主要是针对甲状腺癌和前列腺癌。虽然在几个NPCSs中发现了一个或多个癌症研究部位的发病率增加，但考虑到肿瘤的生态研究设计和多因素病因学，不允许得出与环境污染的因果关系。关于观察到的一些过度的结构性免疫反应，有必要继续进行流行病学监测。
The aim of the present study was to investigate the incidence of breast (females), prostate, testicular, and thyroid cancer in the Italian National Priority Contaminated Sites (NPCSs), served by cancer registries, where the presence of endocrine disruptors (EDs), reported to be linked to these tumours, was documented. Evidence of carcinogenicity of EDs present in NPCSs was assessed based on evaluation by international scientific institutions and committees. Standardized Incidence Ratios (SIRs) were computed for each NPCS and cancer site between 1996 and 2005. Excess incidence of one or more cancer site studied was found in twelve out of fourteen NPCSs. Significantly increased SIRs were found for breast cancer in eight NPCSs, for prostate cancer in six, for thyroid cancer (both gender) in four, and for testicular cancer in two. Non-significantly increased SIRs were found in five NPCSs for testicular cancer and in two for thyroid cancer (males). In a small number of instances a significant deficit was reported, mainly for thyroid and prostate cancer. Although increased incidence of one or more cancer sites studied were found in several NPCSs, the ecological study design and the multifactorial aetiology of the considered tumours do not permit concluding causal links with environmental contamination. Regarding the observation of some excesses in SIRs, continuing epidemiological surveillance is warranted.