Sodium-Metal-Promoted Reductive 1,2-syn-Diboration of Alkynes with Reduction-Resistant Trimethoxyborane
Sodium-Metal-Promoted Reductive 1,2-syn-Diboration of Alkynes with Reduction-Resistant Trimethoxyborane
复制标题
DOI：
10.1246/bcsj.20200110
复制
发表时间：
2020-10-01
影响因子：
4
通讯作者：
Yorimitsu, Hideki
中科院分区：
文献类型：
--
作者：
Ito, Shiori;Fukazawa, Mizuki;Yorimitsu, Hideki
在三甲氧基硼烷作为抗还原硼亲电试剂存在下，通过钠分散体完成了炔的还原1，2-二硼化反应。通过在炔上引入两个硼原子，可以得到相应的（Z）-1，2-二硼烯。原位生成的双硼酸盐物种可以参与一锅Suzuki-Miyaura芳基化反应，从而执行炔的正式芳基硼化。
Reductive 1,2-diboration of alkynes has been accomplished by means of sodium dispersion in the presence of trimethoxy-borane as a reduction-resistant boron electrophile. Two boron moieties can be introduced onto alkynes with excellent syn selectivity to afford the corresponding (Z)-1,2-diborylalkenes. Bis(borate) species generated in situ can be involved in one-pot Suzuki-Miyaura arylation, formal arylboration of alkynes thus being executed.