THE LEVATOR AURIS LONGUS MUSCLE OF THE MOUSE - A CONVENIENT PREPARATION FOR STUDIES OF SHORT-TERM AND LONG-TERM PRESYNAPTIC EFFECTS OF DRUGS OR TOXINS
THE LEVATOR AURIS LONGUS MUSCLE OF THE MOUSE - A CONVENIENT PREPARATION FOR STUDIES OF SHORT-TERM AND LONG-TERM PRESYNAPTIC EFFECTS OF DRUGS OR TOXINS
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DOI：
10.1016/0304-3940(87)90175-3
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发表时间：
1987-11-10
影响因子：
2.5
通讯作者：
FAILLE, L
中科院分区：
文献类型：
--
作者：
ANGAUTPETIT, D;MOLGO, J;FAILLE, L
我们在这里描述了小鼠耳长提肌作为一种方便的神经肌肉准备，用于在体外研究年青或成年小鼠体内应用的药物和毒素的突触前效应。利用诺玛斯基光学系统对其运动轴突和终端的良好可见性使得对突触前信号进行精确的电生理研究成为可能。此外，提耳长肌足够薄，可以作为整个支架进行染色。初步结果表明，A型肉毒杆菌毒素中毒提耳长肌后突触前信号的时间变化与运动末梢形态有一定的相关性。
We describe here the levator auris longus muscle of the mouse as a convenient neuromuscular preparation for the in vitro study of presynaptic effects of drugs and toxins applied in vivo in young or adult mice. The good visibility of its motor axons and terminals using Nomarski optics allows accurate electrophysiological studies of presynaptic signals. In addition, the levator auris longus muscle is sufficiently thin to be stained as a whole mount preparation. Preliminary results indicate that some correlation can be established between changes in time course of the presynaptic signal and the morphology of motor endings after poisoning the levator auris longus muscle with botulinum type A toxin.