1alpha,25-Dihydroxyvitamin D and fish oil synergistically inhibit G1/S-phase transition in prostate cancer cells.
1alpha,25-Dihydroxyvitamin D and fish oil synergistically inhibit G1/S-phase transition in prostate cancer cells.
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1α,25-二羟基维生素 D 和鱼油协同抑制前列腺癌细胞的 G1/S 相转变。
DOI：
10.1016/j.jsbmb.2006.12.011
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Chen,TC
中科院分区：
文献类型：
--
作者：
Istfan,NW;Person,KS;Holick,MF;Chen,TC
Laboratory and epidemiological studies have indicated that 1α,25-dihydroxyvitamin D3[1α,25(OH)2D3] and dietary ω3-polyunsaturated fatty acids (PUFAs) are capable of inhibiting prostate cancer at the initiation and progression stages. The objective of this study is to investigate the influence of 1α,25(OH)2D3and PUFAs in the form of fish oil applied alone or in combination on cell cycle kinetics in the exponentially growing androgen-dependent and -independent prostate cancer cells. Our data indicate that the high passage androgen-independent cell line, LNCaP-c115 had a much greater inhibitory response at the level of the G1/S-phase transition in response to fish oil treatment than androgen-dependent low passage LNCaP-c38 cells. When LNCaP-c38 and LNCaP-c115 cells were treated with fish oil (50μg/ml), 1α,25(OH)2D3(10−8M) or fish oil (50μg/ml)+1α,25(OH)2D3(10−8M), a synergistic growth inhibitory effect was observed with 1α,25(OH)2D3+fish oil group in LNCaP-c115 cell line at the levels of the G1/S-phase transition and cell division. This interaction appears to be specific for androgen-independent prostate cancer cell lines. Based on these results, we hypothesize that dietary components, such as ω3PUFAs and Vitamin D, have the potential to delay the progression of prostate cancer cells to an aggressive and un-treatable state.
