Genetic-epigenetic intersection in trophoblast differentiation Implications for extraembryonic tissue function
Genetic-epigenetic intersection in trophoblast differentiation Implications for extraembryonic tissue function
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DOI：
10.4161/epi.5.1.10589
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发表时间：
2010-01-01
期刊：
影响因子：
3.7
通讯作者：
Hemberger, Myriam
中科院分区：
文献类型：
--
作者：
Hemberger, Myriam
近年来，我们对早期哺乳动物发育的理解取得了相当大的进展，导致了第一个细胞谱系的建立，这对源自早期胚胎的干细胞的行为具有重要意义。引人注目的新见解也推动了表观遗传学领域的发展，5-羟甲基胞嘧啶被鉴定为一种额外的碱基修饰，并且不对称非 CG DNA 甲基化的普遍存在，特别是在 ES 细胞中。受我们关于 DNA 甲基化在细胞谱系定型中的作用的发现的启发，这篇综述重点介绍了对胎盘滋养层谱系建立过程中遗传-表观遗传交叉的最新见解，胎盘滋养层谱系对于胚胎植入、营养和存活至关重要。独特的滋养层表观基因型有助于正常滋养层分化和胎盘功能，因此滋养层特别容易出现重编程失败。
Recent years have seen considerable advances in our understanding of early mammalian development leading up to the establishment of the first cell lineages, with important implications for the behavior of stem cells derived from the early embryo. Dramatic new insights have also propelled the field of epigenetics with the identification of 5-hydroxymethylcytosine as an additional base modification and the pervasiveness of asymmetrical non-CG DNA methylation specifically in ES cells. Prompted by our findings on the role of DNA methylation in cell lineage commitment, this review highlights recent insights into the genetic-epigenetic intersection in the establishment of the placental trophoblast lineage that is essential for embryo implantation, nutrition and survival. The unique trophoblast epigenotype is instrumental for normal trophoblast differentiation and placental function, and consequently trophoblast is particularly susceptible to regrogramming failures.