EFFECTS OF SOME OPIATES AND OPIOID PEPTIDE EYEDROPS ON OCULAR MELATONIN REGULATION IN RABBITS
EFFECTS OF SOME OPIATES AND OPIOID PEPTIDE EYEDROPS ON OCULAR MELATONIN REGULATION IN RABBITS
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DOI：
10.1159/000267340
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发表时间：
1993-11-01
影响因子：
2.1
通讯作者：
CHIOU, GCY
中科院分区：
文献类型：
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作者：
ROHDE, BH;ZHU, M;CHIOU, GCY
采用放射免疫法测定兔眼组织中褪黑素的含量。局部给予甲啡肽、亮啡肽、阿林、α-内啡肽和β-内啡肽溶液。甲硫脑啡肽和α-内啡肽降低了虹膜、虹膜根睫状体、视网膜和脉络膜中的褪黑激素水平;亮脑啡肽升高了视网膜中的褪黑激素水平，降低了其他组织中的褪黑激素水平。β-内啡肽仅降低虹膜根睫状体中的水平。静脉注射DAGO（mu激动剂）可降低虹膜、虹膜根睫状体和视网膜中的褪黑激素水平。静脉内给予的δ和σ激动剂仅降低虹膜根-睫状体中的水平，而静脉内给予的κ激动剂升高睫状体中的水平。在兔虹膜或虹膜根纤毛体上均未检测到阿片受体结合位点。我们的数据表明阿片类药物可能对治疗青光眼有用。
Levels of melatonin in rabbit eye tissues were detected by radioimmunoassay. Solutions of met-enkephalin, leu-enkephalin, alin, alpha-endorphin and beta-endorphin were given topically. Met-Enkephalin and alpha-endorphin lowered levels of melatonin in the iris, iris root-ciliary body, retina and choroid; leu-enkephalin raised levels in the retina and lowered them in other tissues. beta-Endorphin only lowered levels in the iris root-ciliary body. DAGO (a mu agonist) given i.v. lowered levels of melatonin in the iris, iris root-ciliary body and retina. The delta and sigma agonists given i.v. only lowered levels in the iris root-ciliary body, and a kappa agonist given i.v. raised levels in the ciliary body. No opiate binding sites could be detected in the rabbit iris or iris root-ciliay body for any class of receptor. Our data suggest opioids may be useful for treating glaucoma.