Childhood leukaemia and socioeconomic status in England and Wales 1976-2005: evidence of higher incidence in relatively affluent communities persists over time
Childhood leukaemia and socioeconomic status in England and Wales 1976-2005: evidence of higher incidence in relatively affluent communities persists over time
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DOI：
10.1038/bjc.2011.415
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发表时间：
2011-11-22
影响因子：
8.8
通讯作者：
Carpenter, L. M.
中科院分区：
文献类型：
--
作者：
Kroll, M. E.;Stiller, C. A.;Carpenter, L. M.
背景：基于记录的研究通常报告了较高的儿童白血病发病率与较高的社会经济地位(SES)之间的关联，但最近的研究结果不太一致。方法：我们检查了1976-2005年间英格兰和威尔士儿童肿瘤国家登记处的记录，以寻找这种关联的证据。所有符合条件的白血病登记(N=11940)按诊断年份分组，以1981年、1991年和2001年为中心的几十年(N=3748、3922、4270)。使用与这十年相适应的人口普查数据，每个病例的SES由人口普查病房的卡斯泰尔剥夺指数的儿童人口加权五分之一来测量，该指数包含诊断时的地址。结果：在每十年中，最贫穷的五分之一的年龄标准化白血病发生率与最富裕的五分之一的年龄标准化白血病发生率相似。经Poisson回归分析，年龄调整率为0.96(95%可信区间为0.94~0.98；P
BACKGROUND: Record-based studies have generally reported association of higher childhood leukaemia incidence with higher socioeconomic status (SES), but recent findings are less consistent.METHODS: We examined records from the National Registry of Childhood Tumours for evidence of this association in England and Wales during 1976-2005. All eligible leukaemia registrations (N = 11940) were grouped by year of diagnosis in decades centred on census years 1981, 1991 and 2001 (N = 3748, 3922, 4270, respectively). Using data from the census appropriate to the decade, SES for each case was measured by the child-population-weighted quintile of the Carstairs deprivation index of the census ward containing the address at diagnosis.RESULTS: In each decade, the age-standardised leukaemia rate in the poorest quintile was similar to 90% of the rate in the most affluent. Using Poisson regression, the age-adjusted rate ratio per quintile decrease in SES was 0.96 (95% confidence interval 0.94-0.98; P