Probabilistic Entity-Relationship Diagram: A correlation between functional connectivity and spontaneous brain activity during resting state in major depressive disorder.
Probabilistic Entity-Relationship Diagram: A correlation between functional connectivity and spontaneous brain activity during resting state in major depressive disorder.
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概率实体关系图：重度抑郁症静息状态下功能连接与自发大脑活动之间的相关性
DOI：
10.1371/journal.pone.0178386
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Zhang S
中科院分区：
文献类型：
--
作者：
Zhang L;Shi L;Zhang B;Zhao L;Dong Y;Liu J;Lian Z;Liang L;Chen W;Luo X;Pei S;Mo X;Huang W;Ouyang F;Guo B;Liang C;Zhang S
研究背景在抑郁症患者中，静息状态下的功能连接（FC）和自发脑活动（SBA）发生了改变。虽然有很多研究分别描述了抑郁症患者FC和SBA的变化，但尚未发现它们之间的相关性。方法基于Pubmed和Embase进行文献检索，直至2016年4月20日，以识别评价MDD患者静息状态下功能连接和自发脑活动之间变化的相关性的研究。采用概率关系图（PERD）方法进行Meta分析，以直观的方式总结多个因素之间的关系。结果共纳入30篇研究（747例MDD患者和757例健康对照）。在这项研究中，我们证明，功能连接和自发脑活动，这是定量测量的主要分析方法，在海马旁回，眶额皮质（OFC）和中央后回（PCG）减少，并增加在颞叶和左背内侧前额叶皮质（DMPFC）的MDD患者。此外，我们还发现抑郁症患者在缺省模式网络和背侧注意网络中的FC和SBA均呈负相关变化，而在岛状网络、执行控制网络、突显网络和其他网络中的FC和SBA均呈正相关变化。结论MDD患者静息状态下的脑功能连接与自发活动存在相关性改变。此外，我们还采用了最近的荟萃分析方法（PERD），总结和整合了现有的研究结果的不一致性，关于网络功能障碍的MDD。
Background Alterations of functional connectivity (FC) and spontaneous brain activity (SBA) during the resting state has been observed in subjects with major depressive disorder (MDD). Although there are many studies separately describing on the alterations of FC and SBA in major depressive disorder, their correlation are still have not been performed. Methods A literature search based on Pubmed and Embase was conducted until 20 April 2016 to identify studies evaluating the correlation for the alterations between functional connectivity and spontaneous brain activity during resting-state in MDD. Meta-analyses were performed using the Probabilistic Entity-Relationship Diagram (PERD) approach to summarize the relationships among multiple factors in an intuitive manner. Results A total of 30 studies (747 individuals with MDD and 757 healthy controls) met the inclusion criteria. In this study, we demonstrated that the functional connectivity and spontaneous brain activity, which was quantitatively measured by the primary analysis methods, was decreased in the parahippocampal gyrus, orbitofrontal cortex (OFC) and postcentral gyrus (PCG), and increased in insula and left dorsal medial prefrontal cortex (DMPFC) in MDD patients. Furthermore, we found that MDD patients presented negative correlation alterations both FC and SBA in the default mode network and the dorsal attention network, but positive correlation alterations both FC and SBA in the insular network, executive control network, the salience network and the other network. Conclusions Our results first suggested that there were correlation alterations between functional connectivity and spontaneous brain activity during resting-state in patients with MDD. Besides, we applied a recent meta-analysis approach (PERD) to summarize and integrate the inconsistence of the existing findings regarding the network dysfunction of MDD.