Increased plant sterol deposition in vascular tissue characterizes patients with severe aortic stenosis and concomitant coronary artery disease
Increased plant sterol deposition in vascular tissue characterizes patients with severe aortic stenosis and concomitant coronary artery disease
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DOI：
10.1016/j.steroids.2015.03.011
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发表时间：
2015-07-01
期刊：
影响因子：
2.7
通讯作者：
Weingaertner, Oliver
中科院分区：
文献类型：
--
作者：
Luister, Alexandra;Schoett, Hans Frieder;Weingaertner, Oliver
该研究的目的是评估计划择期主动脉瓣置换术的严重主动脉狭窄患者的植物甾醇、氧化植物甾醇和其他胆固醇代谢标志物与伴随冠状动脉疾病（CAD）之间的关系。采用气相色谱-火焰电离和质谱法测定了连续104例重度主动脉瓣狭窄患者（68例接受他汀类药物治疗，36例未接受他汀类药物治疗）血浆和主动脉瓣组织中的胆固醇代谢标志物（作为胆固醇吸收标志物的植物甾醇和胆固醇合成指标的植物甾醇）和氧化植物甾醇。主动脉瓣置换术前通过冠状动脉造影确定冠心病的程度。接受他汀类药物治疗的患者的特点是血浆胆固醇、胆固醇和胆甾醇浓度降低。然而，他汀类药物治疗不影响心血管组织中的固醇浓度。冠心病患者血浆中油菜甾醇/胆固醇比值升高0.46±034 μ g/mg（26.0%）。与没有合并冠心病的患者相比，有记录的冠心病患者组织中胆固醇吸收标志物谷甾醇和油菜甾醇的绝对值分别增加了18.18 +/- 11.59 ng/mg（38.8%）和11.40 +/- 8.69 ng/mg（30.4%）。冠心病患者主动脉瓣尖的甘油酯氧化物升高0.06 +/- 0.02 ng/mg(17.1%)，血浆中氧化谷甾醇/胆固醇比值升高0.35 0.2 ng/mg（22.7%）。值得注意的是，胆固醇和胆固醇与胆固醇的比值都与冠心病无关。合并冠心病患者的特征是植物甾醇沉积增加，而不是胆固醇沉积在主动脉瓣组织中。此外，合并冠心病患者的特点是血浆和主动脉瓣尖的氧化植物甾醇浓度升高。(C) 2015爱思唯尔公司版权所有。
The aim of the study was to evaluate the relationship between phytosterols, oxyphytosterols, and other markers of cholesterol metabolism and concomitant coronary artery disease (CAD) in patients with severe aortic stenosis who were scheduled for elective aortic valve replacement.Markers of cholesterol metabolism (plant sterols and cholestanol as markers of cholesterol absorption and lathosterol as an indicator of cholesterol synthesis) and oxyphytosterols were determined in plasma and aortic valve tissue from 104 consecutive patients with severe aortic stenosis (n = 68 statin treatment; n = 36 no statin treatment) using gas chromatography-flame ionization and mass spectrometry. The extent of CAD was determined by coronary angiography prior to aortic valve replacement.Patients treated with statins were characterized by lower plasma cholesterol, cholestanol, and lathosterol concentrations. However, statin treatment did not affect the sterol concentrations in cardiovascular tissue. The ratio of campesterol-to-cholesterol was increased by 0.46 +/- 034 mu g/mg (26.0%) in plasma of patients with CAD. The absolute values for the cholesterol absorption markers sitosterol and campesterol were increased by 18.18 +/- 11.59 ng/mg (38.8%) and 11.40 +/- 8.69 ng/mg (30.4%) in the tissues from patients with documented CAD compared to those without concomitant CAD. Campesterol oxides were increased by 0.06 +/- 0.02 ng/mg (17.1%) in the aortic valve cusps and oxidized sitosterol-to-cholesterol ratios were up-regulated by 0.35 0.2 ng/mg (22.7%) in the plasma of patients with CAD. Of note, neither cholestanol nor the ratio of cholestanol-to-cholesterol was associated with CAD.Patients with concomitant CAD are characterized by increased deposition of plant sterols, but not cholestanol in aortic valve tissue. Moreover, patients with concomitant CAD were characterized by increased oxyphytosterol concentrations in plasma and aortic valve cusps. (C) 2015 Elsevier Inc. All rights reserved.