Mortality and survival for Minamata disease.
Mortality and survival for Minamata disease.
复制标题
水俣病的死亡率和生存率。
DOI：
10.1093/ije/14.4.582
复制
发表时间：
1985
影响因子：
7.7
通讯作者：
L. Roht
中科院分区：
文献类型：
--
作者：
H. Tamashiro;M. Arakaki;H. Akagi;M. Futatsuka;L. Roht
从1981年底开始，对日本熊本县1483例水螅病（MD）患者中439例死亡进行了死亡率分析。采用标准化死亡比（SMR）和寿命表技术研究死亡原因和生存率。在439例MD死亡病例中（29.6%），第一例死亡发生在1954年。在1956年MD首次报告时出现了第一个发病高峰，然而，大多数死亡发生在1972年之后，当时第二个更大的高峰明显。1970年，一个重要的里程碑发生在公共营养救济法（反污染法）颁布时。在其规定中，这项法律要求并允许对怀疑接触过的人进行MD核查。与早期病例相比，后来的MD病例年龄更大，其平均死亡年龄与一般人群没有差异。与一般人口相比，男女的所有死亡原因的死亡率都高得多。老年患者的生存率明显较低。原因特异性死亡率还显示，男性患者中肝病和肾炎-肾病-肾病综合征的SMR显著增加，女性患者中肾炎-肾病-肾病综合征和其他疾病的SMR显著增加。另一方面，两种性别中未提及精神病的衰老SMR均显著低于预期。
Analysis of mortality of 439 deaths that occurred among 1483 patients with Minamata disease (MD) in Kumamoto Prefecture, Japan was performed from the end of 1981. Causes of death and survival rates were studied by means of the standardized mortality ratio (SMR) and life-table technique. Of the 439 deaths (29.6%) in MD cases, the first death occurred in 1954. There was a first peak incidence in 1956 when MD was initially reported, however, the majority of deaths occurred after 1972 when a second and much larger peak was evident. In 1970 an important milestone occurred when the Public Nuisance Relief Law (an anti-pollution law) was enacted. Among its provisions, this law required and enabled verification of MD among people suspected of having been exposed. In contrast to the early cases, later cases of MD were older and their mean age-at-death was not different from that of the general population. The mortality rate for all causes of death was significantly higher in both sexes compared to the general population. Significantly lower survival rates were noted for older patients. The cause-specific mortality rates also showed significantly increased SMRs for liver diseases and nephritis-nephrosis-nephrotic syndrome in male patients, and for nephritis-nephrosis-nephrotic syndrome and other diseases in females. On the other hand, the SMR for senility without mention of psychosis was significantly lower than expected in both sexes.