Survival differences exhibited by normal and transformed rat liver epithelial cell lines in the aggregate form.
Survival differences exhibited by normal and transformed rat liver epithelial cell lines in the aggregate form.
复制标题
正常和转化的大鼠肝上皮细胞系以聚集形式表现出存活差异。
作者：
A. F. Steuer;P. Hentosh;L. Diamond;R. Ting
正常和转化的大鼠肝上皮细胞系表现出不同的生存能力的聚集体形式。正常大鼠肝上皮细胞的聚集体形式经历了一个快速下降的活细胞的数量，而对应的转化上皮细胞表现出的能力，生存和增殖的聚集体形式。这种存活能力与软琼脂集落形成和裸鼠成瘤性有关。聚集体形式的细胞存活可能作为体外转化大鼠肝上皮细胞的标准。
Normal and transformed rat liver epithelial cell lines exhibited differences in the ability to survive in the aggregate form. Normal rat liver epithelial cells in the aggregate form underwent a rapid decline in the number of viable cells, while counterpart transformed epithelial cells exhibited an ability to survive and proliferate in the aggregate form. This survival ability was found to correlate with colony formation in soft agar and tumorigenicity in nude mice. Cell survival in the aggregate form could possibly serve as a criterion for in vitro transformation of epithelial cells derived from rat liver.