WormBase:: better software, richer content
WormBase:: better software, richer content
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DOI：
10.1093/nar/gkj061
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发表时间：
2006-01-01
影响因子：
14.9
通讯作者：
Sternberg, Paul W.
中科院分区：
文献类型：
--
作者：
Schwarz, Erich M.;Antoshechkin, Igor;Sternberg, Paul W.
WormBase（wormbase.org）是秀丽隐杆线虫基因组学和生物学的公共数据库，已进行了重组，以提高性能，并扩大了内容，以增加生物学内容。通过加速诸如综合基因页面的中央数据页面的加载，通过合理化内部数据结构和软件以获得更大的可移植性，以及通过使基因组浏览器在如何查看和导出基因组序列方面具有高度可定制性，来提高性能。通过Textbook（对于所有可用的文献）和WormMart（对于大多数基因组数据），现在可以进行非常复杂的、用户指定的查询。生物学内容丰富，通过调和所有可用的cDNA和表达的序列标签数据与基因预测，澄清单核苷酸多态性和RNAi位点，并总结已知的功能，在这种生物体中研究的大多数基因。
WormBase (http://wormbase.org), the public database for genomics and biology of Caenorhabditis elegans, has been restructured for stronger performance and expanded for richer biological content. Performance was improved by accelerating the loading of central data pages such as the omnibus Gene page, by rationalizing internal data structures and software for greater portability, and by making the Genome Browser highly customizable in how it views and exports genomic subsequences. Arbitrarily complex, user-specified queries arenowpossible through Textpresso (for all available literature) and through WormMart (for most genomic data). Biological content was enriched by reconciling all available cDNA and expressed sequence tag data with gene predictions, clarifying single nucleotide polymorphism and RNAi sites, and summarizing known functions for most genes studied in this organism.